Artificial Cytotoxic T Lymphocytes Selectively Eliminate Tumor Cells for Effective Cancer Therapy.

IF 9.6 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Weijia Xu, Mingda Yang, Jihong Wang, Jie Li, Menghua Xiong, Ziyang Cao, Xianzhu Yang
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Abstract

The highly selective ability of cytotoxic T lymphocytes (CTLs) to eliminate tumor cells has inspired the development of artificial nanomedicine for effective cancer therapy. Here, an artificial CTL (aCTL) that selectively recognizes and kills cancer cells is developed. The membrane target-binding moiety, membrane-perforating peptides, and therapeutic prodrugs are integrated into the aCTL through supramolecular interactions. Consequently, the prepared aCTL selectively binds cancer cells and perforates the surrounding membrane. Subsequently, the conjugated prodrug is cleaved and released by the overexpressed membrane transpeptidase, allowing entry into tumor cells through the perforated holes. Finally, the aCTL significantly suppresses the growth of HepG2 hepatocellular carcinoma, B16-F10 melanomas, and patient-derived xenograft (PDX) breast cancer models.

Abstract Image

人工细胞毒性T淋巴细胞选择性清除肿瘤细胞,有效治疗癌症。
细胞毒性T淋巴细胞(ctl)清除肿瘤细胞的高度选择性能力激发了用于有效癌症治疗的人工纳米药物的发展。在这里,人工CTL (aCTL)选择性识别和杀死癌细胞被开发。膜靶标结合片段、穿膜肽和治疗前药通过超分子相互作用整合到aCTL中。因此,制备的aCTL选择性地结合癌细胞并穿透周围的膜。随后,结合的前药被切裂并被过表达的膜转肽酶释放,允许通过穿孔孔进入肿瘤细胞。最后,aCTL显著抑制HepG2肝细胞癌、B16-F10黑色素瘤和患者源性异种移植(PDX)乳腺癌模型的生长。
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来源期刊
Nano Letters
Nano Letters 工程技术-材料科学:综合
CiteScore
16.80
自引率
2.80%
发文量
1182
审稿时长
1.4 months
期刊介绍: Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.
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