{"title":"Progress of p53 Involvement in Central Nervous System Diseases and Targeted Drug Discovery","authors":"Fenglian Xu, Zijun Liu, Ziyu Wang, Yi Zhang, Yu Zhao, Weirong Fang","doi":"10.1002/cbf.70089","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>p53 plays a critical role in the pathogenesis of central nervous system (CNS) diseases, including neurodegenerative diseases, stroke, and neurodevelopmental disorders. Recent studies have shown that p53 regulates pathological processes such as apoptosis, ferroptosis, neuroinflammation, mitochondrial dysfunction, DNA damage, and synaptic dysfunction through complex molecular pathways. Preclinical studies have demonstrated that pharmacological inhibition or knockdown of p53 exerts neuroprotective effects, suggesting its potential therapeutic value. This review systematically summarizes the mechanisms of p53 in CNS diseases and the associated signaling pathways involved in these pathological processes. Additionally, p53-related intervention strategies in CNS diseases and challenges to the development of p53-targeted drugs are summarized, aiming to provide new insights for therapeutic treatment.</p></div>","PeriodicalId":9669,"journal":{"name":"Cell Biochemistry and Function","volume":"43 6","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biochemistry and Function","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbf.70089","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
p53 plays a critical role in the pathogenesis of central nervous system (CNS) diseases, including neurodegenerative diseases, stroke, and neurodevelopmental disorders. Recent studies have shown that p53 regulates pathological processes such as apoptosis, ferroptosis, neuroinflammation, mitochondrial dysfunction, DNA damage, and synaptic dysfunction through complex molecular pathways. Preclinical studies have demonstrated that pharmacological inhibition or knockdown of p53 exerts neuroprotective effects, suggesting its potential therapeutic value. This review systematically summarizes the mechanisms of p53 in CNS diseases and the associated signaling pathways involved in these pathological processes. Additionally, p53-related intervention strategies in CNS diseases and challenges to the development of p53-targeted drugs are summarized, aiming to provide new insights for therapeutic treatment.
期刊介绍：
Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease.
The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.
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