Animal Models: A Tool for Colon Cancer Research

IF 2.8 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2025-06-10 DOI:10.1002/cbf.70087

LokeshKumar Boopathy, Sasikumar Arumugam, Kumar Ponnusamy, Siddarth Srigokul Kumar, Thiyagarajan Gopal, Saravanan Durai, Sriramkumar Ravikumar, Madan Kumar Arumugam

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引用次数: 0

Abstract

Preclinical animal research plays a crucial role in studying colorectal cancer (CRC). Mouse models allow for testing the efficacy of potential medications and understanding the mechanisms behind CRC development. Carcinogens like 1,2-Dimethylhydrazine (DMH) and Azoxymethane (AOM) are used to induce CRC in these models, enabling researchers to investigate various treatment approaches. The availability of diverse animal strains facilitates the study of CRC progression and metastasis. By examining literature on animal models, researchers can assess the accuracy of reproducing different stages of CRC, from crypts to polyps and tumors. Animal models are essential for studying the tumor microenvironment and its impact on CRC. These models replicate key features of human CRC, including angiogenesis and immune responses. Both immunocompetent and immunocompromised rodents are used to evaluate immunotherapeutic drugs. This review summarizes common murine models for CRC and their applications in translational research. Future trends in this field likely include further advancements in animal models for studying tumor biology.

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动物模型：结肠癌研究的工具

临床前动物研究在研究结直肠癌（CRC）中起着至关重要的作用。小鼠模型允许测试潜在药物的功效和了解CRC发展背后的机制。在这些模型中，1,2-二甲基肼（DMH）和偶氮氧甲烷（AOM）等致癌物被用于诱导结直肠癌，使研究人员能够探索各种治疗方法。多种动物菌株的可用性有助于研究结直肠癌的进展和转移。通过查阅动物模型的文献，研究人员可以评估复制CRC不同阶段（从隐窝到息肉和肿瘤）的准确性。动物模型对于研究肿瘤微环境及其对结直肠癌的影响至关重要。这些模型复制了人类结直肠癌的关键特征，包括血管生成和免疫反应。免疫功能正常和免疫功能低下的啮齿类动物被用来评估免疫治疗药物。本文综述了常用的CRC小鼠模型及其在转译研究中的应用。该领域的未来趋势可能包括进一步发展用于研究肿瘤生物学的动物模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.