Chitinase-3-Like 1 Protein (CHI3L1) Levels in Patients With Cognitive Deficits and Movement Disorders: Comparison With Other Biomarkers

IF 2.6 3区 心理学 Q2 BEHAVIORAL SCIENCES
R. Novobilský, P. Bártová, D. Stejskal, A. Kondé, M. Bar, P. Kušnierová
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引用次数: 0

Abstract

Introduction

Chitinase-3-like protein 1 (CHI3L1) is a glycoprotein implicated in various neurological conditions. It is associated with neuroinflammation and tissue remodeling. The study aimed to validate the reference interval (RI) of serum (S) CHI3L1 in a control group, to correlate S CHI3L1 values with other biomarkers of neurodegenerative damage, and to estimate the diagnostic accuracy of S CHI3L1.

Methods

Samples from 108 healthy volunteers were used to estimate the S CHI3L1 RI. For the comparison, we used cerebrospinal fluid (CSF) and serum (S) samples from 121 patients with cognitive disorders, and cognitive deterioration was assessed using the Mini-Mental State Examination (MMSE). ELISA assays were used to determine the S CHI3L1, CSF, and S neurofilament light chain (NfL) levels; CSF and plasma β-amyloid peptide42; CSF and plasma β-amyloid peptide40; CSF total tau protein; CSF phosphorylated tau protein; and CSF alpha-synuclein.

Results

The estimated RI of S CHI3L1 was 14.44 to 63.11 µg/L. The cut-off value of S CHI3L1 was 34.37 µg/L. ROC analysis showed that S CHI3L1 has 81.4% sensitivity and 76.9% specificity. We found a moderate Spearman's rank correlation coefficient between the S CHI3L1 and age (r= 0.486; p < 0.001) and between S CHI3L1 and S NfL (rS = 0.489; p < 0.001) in all groups. The Kruskal–Wallis test showed a significant overall difference in S CHI3L1 among diagnostic groups (p = 0.013). S CHI3L1 and CSF NfL had statistically significant effects on MMSE values (multiple R2 was 0.431).

Conclusions

Our results suggest that S CHI3L1 reflects the severity of cognitive deficits assessed by MMSE. It can be used as a supportive biomarker in neurodegenerative diseases.

Abstract Image

认知缺陷和运动障碍患者的几丁质酶-3样1蛋白(CHI3L1)水平:与其他生物标志物的比较
几丁质酶-3样蛋白1 (CHI3L1)是一种与多种神经系统疾病有关的糖蛋白。它与神经炎症和组织重塑有关。本研究旨在验证对照组血清(S) CHI3L1的参考区间(RI),将S CHI3L1值与神经退行性损伤的其他生物标志物相关联,并估计S CHI3L1的诊断准确性。方法采用108例健康志愿者标本,测定S - CHI3L1 RI。为了进行比较,我们使用121例认知障碍患者的脑脊液(CSF)和血清(S)样本,并使用迷你精神状态检查(MMSE)评估认知退化。ELISA法检测S CHI3L1、CSF和S神经丝轻链(NfL)水平;脑脊液和血浆β-淀粉样肽42;脑脊液和血浆β-淀粉样肽40;脑脊液总tau蛋白;脑脊液磷酸化tau蛋白;和CSF -突触核蛋白。结果S CHI3L1的RI值为14.44 ~ 63.11µg/L。S CHI3L1的截止值为34.37µg/L。ROC分析显示S CHI3L1的敏感性为81.4%,特异性为76.9%。我们发现S - CHI3L1与年龄有中等的Spearman等级相关系数(rS = 0.486;p & lt;0.001), S CHI3L1与S NfL之间(rS = 0.489;p & lt;0.001)。Kruskal-Wallis检测显示S CHI3L1在诊断组间的总体差异有统计学意义(p = 0.013)。S CHI3L1和CSF NfL对MMSE值的影响有统计学意义(多重R2为0.431)。结论:我们的研究结果表明,S CHI3L1反映了MMSE评估的认知缺陷的严重程度。它可以作为神经退行性疾病的支持性生物标志物。
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来源期刊
Brain and Behavior
Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
5.30
自引率
0.00%
发文量
352
审稿时长
14 weeks
期刊介绍: Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior. * [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica) * [Addiction Biology](https://publons.com/journal/1523/addiction-biology) * [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior) * [Brain Pathology](https://publons.com/journal/1787/brain-pathology) * [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development) * [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health) * [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety) * Developmental Neurobiology * [Developmental Science](https://publons.com/journal/1069/developmental-science) * [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience) * [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior) * [GLIA](https://publons.com/journal/1287/glia) * [Hippocampus](https://publons.com/journal/1056/hippocampus) * [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping) * [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour) * [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology) * [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging) * [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research) * [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior) * [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system) * [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve) * [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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