High-Definition Transcranial Direct Current Stimulation Enhances Exercise-Induced Hypoalgesia in Healthy Individuals: An fNIRS Study

IF 2.7 3区心理学 Q2 BEHAVIORAL SCIENCES

Brain and Behavior Pub Date : 2025-06-10 DOI:10.1002/brb3.70595

Ruihan Wan, Haozhi Zhao, Xue Jiang, Beibei Feng, Yafei Wang, Chen Gong, Yangyang Lin, Wangwang Yan, Yixuan Ku, Yuling Wang

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引用次数: 0

Abstract

Background

This study investigates whether anodal high-definition transcranial direct current stimulation (HD-tDCS) enhances exercise-induced hypoalgesia (EIH) and explores brain plasticity changes using functional near-infrared spectroscopy (fNIRS).

Methods

Thirty-nine participants were randomly assigned to either the active (n = 19) or sham HD-tDCS (n = 20) group. Both groups performed 25 min of moderate-intensity aerobic exercise followed by 20 min of either active or sham HD-tDCS applied to the left primary motor cortex (M1). Primary outcome: pressure pain threshold (PPT) at a local site. Secondary outcomes: PPT at a remote site, cold pain threshold (CPT), and brain activation changes via fNIRS during the cold pressor test.

Results

Both groups showed significant increases in PPT_leg (active: from 42.21 ± 11.77 N to 51.29 ± 12.75 N; sham: from 41.41 ± 9.73 N to 45.29 ± 12.05 N, p < 0.001) and PPT_forearm (active: from 31.69 ± 6.06 N to 36.99 ± 6.35 N; sham: from 32.66 ± 7.34 N to 37.08 ± 10.56 N, p < 0.001). The active group showed a significantly greater increase in PPT_leg compared to the sham group (9.08 ± 8.01 N vs. 3.69 ± 4.36 N, p < 0.012). fNIRS analysis revealed significant changes in specific cortical channels in the active group (p < 0.05), with a negative correlation between cortical activation in CH16 and PPTleg (r = −0.405, p = 0.011).

Conclusion

HD-tDCS over M1 enhances EIH and is associated with increased brain activation in sensory-motor processing areas.

Trial Registration

Clinical trial registration: ChiCTR2100048146

Abstract Image

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高清晰度经颅直流电刺激增强健康个体运动诱导的痛觉减退：一项fNIRS研究

本研究探讨了阳极高清晰度经颅直流电刺激（HD-tDCS）是否会增强运动性痛觉减退（EIH），并利用功能近红外光谱（fNIRS）研究了大脑可塑性的变化。方法将39名受试者随机分为活跃组（n = 19）和假手术组（n = 20）。两组都进行了25分钟的中等强度有氧运动，然后对左初级运动皮层（M1）进行了20分钟的活动或假HD-tDCS。主要观察指标：局部压痛阈值（PPT）。次要结果：远端部位PPT、冷痛阈值（CPT）和冷压试验期间fNIRS脑激活变化。结果两组ppleg活性均显著升高，由42.21±11.77 N增至51.29±12.75 N；假：从41.41±9.73北纬至45.29±12.05北纬，p <；0.001)和ppt前臂(活性范围：从31.69±6.06 N到36.99±6.35 N；假：从32.66±7.34北纬到37.08±10.56北纬，p <；0.001)。活性组ppleg明显高于假手术组(9.08±8.01 N比3.69±4.36 N, p <；0.012)。fNIRS分析显示，活性组特定皮质通道发生显著变化(p <；CH16皮质活化与ppleg呈负相关（r = - 0.405, p = 0.011）。结论M1上HD-tDCS增强EIH，并与感觉-运动加工区激活增加有关。临床试验注册：ChiCTR2100048146

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来源期刊

Brain and Behavior BEHAVIORAL SCIENCES-NEUROSCIENCES

CiteScore

5.30

自引率

0.00%

发文量

352

审稿时长

14 weeks

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