The value of ultrasonic attenuation parameters and serum indicators on MASLD patients with liver fat degenerationality

IF 2.5 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2025-06-10 DOI:10.1016/j.jrras.2025.101647

Yan Liu , Wen Kang , Jingya Su , Yin Yang , Kui Li , Juntao Yang

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引用次数: 0

Abstract

Objective

To explore the diagnostic value of controlled attenuation parameters combined with serum biochemical indicators for metabolic dysfunction–associated steatotic liver disease (MASLD).

Methods

A total of 145 patients with MASLD who visited our hospital from January 2023 to June 2024 were included. 55 healthy subjects were used as controls. The ROC curve was drawn with the CT liver/spleen ratio as the diagnostic standard, and the area under the curve was calculated to evaluate the diagnostic value of fat attenuation parameters for MASLD.

Results

The best cut-off value of the fat attenuation parameter for diagnosing fatty liver was 262.5 dB/m (AUROC = 0.823, sensitivity = 0.820, specificity = 0.701, P < 0.05). The best cut-off values of fat attenuation parameters for diagnosing mild, moderate, and severe fatty liver were 225.5 dB/m, 267.5 dB/m, and 289.5 dB/m, respectively, with AUROC of 0.440, 0.665, and 0.808, all P < 0.05. The combination of fat attenuation parameter with alanine aminotransferase or triglyceride can enhance the diagnostic value of MASLD, and the diagnostic efficacy of fat attenuation parameter combined with ALT was substantially higher, the AUROC was 0.776, 0.924, and 0.997, all P < 0.05.

Conclusion

Ultrasound controlled attenuation parameters combined with ALT and TG have near-perfect diagnostic accuracy. for MASLD.

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超声衰减参数及血清指标在MASLD合并肝脂肪变性患者中的价值

目的探讨控制衰减参数联合血清生化指标对代谢功能障碍相关性脂肪变性肝病（MASLD）的诊断价值。方法选取2023年1月至2024年6月在我院就诊的MASLD患者145例。55名健康受试者作为对照。以CT肝脾比值为诊断标准，绘制ROC曲线，计算曲线下面积，评价脂肪衰减参数对MASLD的诊断价值。结果脂肪衰减参数诊断脂肪肝的最佳临界值为262.5 dB/m (AUROC = 0.823，敏感性= 0.820，特异性= 0.701,P <；0.05)。诊断轻度、中度、重度脂肪肝脂肪衰减参数的最佳临界值分别为225.5 dB/m、267.5 dB/m、289.5 dB/m， AUROC分别为0.440、0.665、0.808，均P <；0.05. 脂肪衰减参数与丙氨酸转氨酶或甘油三酯联合使用可增强对MASLD的诊断价值，且脂肪衰减参数与ALT联合使用的诊断效能明显更高，AUROC分别为0.776、0.924和0.997，均P <；0.05.结论超声控制衰减参数与ALT、TG联合诊断具有接近完美的准确性。MASLD。

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来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.