Brain cell activity detection using optical grating-based surface plasmonic resonance sensor

IF 4.9 Q1 CHEMISTRY, ANALYTICAL
Masoumeh Taghilou , Vahid Ahmadi , Javad Mirnajafi-Zadeh
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引用次数: 0

Abstract

Optical neural recordings are label-free and non-toxic as compared to the other methods. We introduce a compact and reliable membrane activity detection sensor based on surface plasmon resonance (SPR) and optical grating. We utilized a fiber optic port to direct light to the optical grating, allowing us to avoid bulky optical setups. Commercial DVD serves as the optical grating, which is both cost-effective and of high quality. In this sensor, we place mouse hippocampal tissue on the Au-sputtered gratings, and by measuring the reflectance spectrum, we investigate the SPR wavelength shift. The introduction of a high-K+ aCSF solution allows us to easily observe the effect of cell depolarization on the SPR wavelength can easily be observed. The proposed sensor achieves a high sensitivity of 628.06 nm/RIU.
基于光学光栅表面等离子体共振传感器的脑细胞活动检测
与其他方法相比,光学神经记录是无标签和无毒的。介绍了一种基于表面等离子体共振(SPR)和光学光栅的紧凑可靠的膜活性检测传感器。我们利用光纤端口将光线引导到光学光栅,从而避免了笨重的光学装置。商用DVD作为光学光栅,既具有性价比,又具有高质量。在该传感器中,我们将小鼠海马组织放置在au溅射光栅上,并通过测量反射光谱来研究SPR波长位移。高k + aCSF溶液的引入使我们可以很容易地观察到细胞去极化对SPR波长的影响,可以很容易地观察到。该传感器具有628.06 nm/RIU的高灵敏度。
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来源期刊
Sensing and Bio-Sensing Research
Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering
CiteScore
10.70
自引率
3.80%
发文量
68
审稿时长
87 days
期刊介绍: Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.
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