“Cancer progression through systemic signaling viewed from Drosophila”

IF 4.3 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-06-11 DOI:10.1016/j.ceb.2025.102545

Masato Enomoto , Shizue Ohsawa

引用次数: 0

Abstract

Cancers develop through local interactions between tumor cells and neighboring cells within the tissue micro environment, while distinct organs regulate cancer progression and suppression via systemic factors. Recent studies in Drosophila have revealed systemic signaling pathways that influence tumor development. This review summarizes the mechanisms by which organ-derived molecules remotely trigger tumor growth and suppression. Additionally, we discuss how tumors dysregulate various organ systems, leading to animal mortality.

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“从果蝇的系统信号看癌症进展”

肿瘤通过组织微环境中肿瘤细胞与邻近细胞的局部相互作用而发展，而不同的器官通过全身因素调节肿瘤的进展和抑制。最近对果蝇的研究揭示了影响肿瘤发展的系统性信号通路。本文综述了器官源性分子远程触发肿瘤生长和抑制的机制。此外，我们讨论肿瘤如何失调各种器官系统，导致动物死亡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.