A review of spatial transcriptomics in psoriasis: new insights into cellular contributions

IF 6.6 2区医学 Q1 IMMUNOLOGY

Current Opinion in Immunology Pub Date : 2025-06-11 DOI:10.1016/j.coi.2025.102585

Andrea Leung , Georgia Marquez-Grap, Allison Kranyak, Wilson Liao

引用次数: 0

Abstract

Spatial transcriptomics (ST) is a technology that has advanced our understanding of the cellular and genetic characteristics of conditions like psoriasis, cancer, and neurodegenerative diseases. ST is often used in conjunction with methods like single-cell RNA sequencing (scRNA-seq), which is a popular method to investigate cellular gene expression. Together, ST and scRNA-seq allow for the visualization and quantification of gene expression spatially, with the preservation of tissue architecture. In psoriasis research, ST and scRNA-seq have led to the identification of distinct cell populations within the skin, associated dysregulated pathways, and critical insight into tissue microenvironments and cell-to-cell interactions. In this review, we provide a summary of how ST has been utilized to better understand psoriasis and how it has shaped our understanding of prominent cell types in psoriasis.

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银屑病的空间转录组学综述：细胞贡献的新见解

空间转录组学（ST）是一项技术，它提高了我们对牛皮癣、癌症和神经退行性疾病等疾病的细胞和遗传特征的理解。ST通常与单细胞RNA测序（scRNA-seq）等方法结合使用，后者是研究细胞基因表达的常用方法。同时，ST和scRNA-seq允许可视化和定量基因表达的空间，与组织结构的保存。在银屑病研究中，ST和scRNA-seq已经鉴定出皮肤内不同的细胞群，相关的失调通路，以及对组织微环境和细胞间相互作用的关键见解。在这篇综述中，我们总结了如何利用ST来更好地了解牛皮癣，以及它如何影响我们对牛皮癣主要细胞类型的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.