{"title":"Mechanical testing of rubber-like 3D printing materials for cardiovascular modeling applications","authors":"Benigno Marco Fanni , Emanuele Gasparotti , Emanuele Vignali , Federica Giovannini , Giovan Battista Semplici , Giovanni Vozzi , Simona Celi","doi":"10.1016/j.jmbbm.2025.107075","DOIUrl":null,"url":null,"abstract":"<div><div>Three-dimensional (3D) printing has attracted considerable attention in cardiovascular applications, offering potential in both clinical practice and in vitro studies. Accurate reproduction of cardiovascular structures depends not only on imaging accuracy but also on the mechanical properties of printed materials. This study focuses on the mechanical characterization of a new series of rubber-like materials, the <em>Vessel Wall</em> (<span><math><mrow><mi>V</mi><mi>W</mi></mrow></math></span>) series, designed specifically for cardiovascular applications. Six material blends, with increasing stiffness levels, were evaluated through uniaxial and biaxial tensile tests to assess their mechanical behavior and potential suitability for vascular modeling. Results from uniaxial tests showed that the <span><math><mrow><mi>V</mi><msub><mrow><mi>W</mi></mrow><mrow><mn>1</mn></mrow></msub></mrow></math></span>, <span><math><mrow><mi>V</mi><msub><mrow><mi>W</mi></mrow><mrow><mn>2</mn></mrow></msub></mrow></math></span> and <span><math><mrow><mi>V</mi><msub><mrow><mi>W</mi></mrow><mrow><mn>3</mn></mrow></msub></mrow></math></span> materials present elastic moduli between 0.7 and 0.9 MPa, within the range of compliant vascular tissues, while the stiffer blends (<span><math><mrow><mi>V</mi><msub><mrow><mi>W</mi></mrow><mrow><mn>4</mn></mrow></msub></mrow></math></span>–<span><math><mrow><mi>V</mi><msub><mrow><mi>W</mi></mrow><mrow><mn>6</mn></mrow></msub></mrow></math></span>), with stiffness in the range 1.1–3.2 MPa, may be more suitable for representing pathological or device-interaction scenarios. An overall isotropic behavior was observed, with minimal influence of print orientation on the mechanical response. In biaxial tests, stress correlation between orthogonal directions showed high linearity (R<span><math><msup><mrow></mrow><mrow><mn>2</mn></mrow></msup></math></span> = 0.97 ± 0.02), confirming the isotropic mechanical behavior of all blends. In conclusion, the <span><math><mrow><mi>V</mi><mi>W</mi></mrow></math></span> series offers a tunable and reproducible set of materials, with elastic properties comparable to cardiovascular tissue, although not capturing their complex mechanical behavior. This study provides a practical reference for an informed selection of materials for different cardiovascular modeling scenarios.</div></div>","PeriodicalId":380,"journal":{"name":"Journal of the Mechanical Behavior of Biomedical Materials","volume":"170 ","pages":"Article 107075"},"PeriodicalIF":3.5000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Mechanical Behavior of Biomedical Materials","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1751616125001912","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Three-dimensional (3D) printing has attracted considerable attention in cardiovascular applications, offering potential in both clinical practice and in vitro studies. Accurate reproduction of cardiovascular structures depends not only on imaging accuracy but also on the mechanical properties of printed materials. This study focuses on the mechanical characterization of a new series of rubber-like materials, the Vessel Wall () series, designed specifically for cardiovascular applications. Six material blends, with increasing stiffness levels, were evaluated through uniaxial and biaxial tensile tests to assess their mechanical behavior and potential suitability for vascular modeling. Results from uniaxial tests showed that the , and materials present elastic moduli between 0.7 and 0.9 MPa, within the range of compliant vascular tissues, while the stiffer blends (–), with stiffness in the range 1.1–3.2 MPa, may be more suitable for representing pathological or device-interaction scenarios. An overall isotropic behavior was observed, with minimal influence of print orientation on the mechanical response. In biaxial tests, stress correlation between orthogonal directions showed high linearity (R = 0.97 ± 0.02), confirming the isotropic mechanical behavior of all blends. In conclusion, the series offers a tunable and reproducible set of materials, with elastic properties comparable to cardiovascular tissue, although not capturing their complex mechanical behavior. This study provides a practical reference for an informed selection of materials for different cardiovascular modeling scenarios.
期刊介绍:
The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials.
The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.