Spectosis: Dying for a complement

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-06-10 DOI:10.1016/j.immuni.2025.05.017

Jared R. Coombs, Sabrina S. Burgener, Kate Schroder

引用次数: 0

Abstract

Red blood cells (RBCs) undergo pathological cell death in hemolytic diseases. In a recent issue of Cell, Chen et al. reveal a mode of programmed cell death, spectosis, in which complement activation initiates (mini)NLRP3-caspase-8 complexes, culminating in hemolysis.

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Spectosis：渴望补充

溶血性疾病中，红细胞（rbc）发生病理性细胞死亡。在最近一期的Cell杂志上，Chen等人揭示了一种程序性细胞死亡模式，即特异性死亡，其中补体激活启动（迷你）NLRP3-caspase-8复合物，最终导致溶血。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.