Correlation between plasma Afamin and gestational diabetes mellitus during pregnancy.

Ginekologia polska Pub Date : 2025-06-09 DOI:10.5603/gpl.103660

Xiang Cheng, Hongyan Cui, Xinran Xu, Nini Jiang

{"title":"Correlation between plasma Afamin and gestational diabetes mellitus during pregnancy.","authors":"Xiang Cheng, Hongyan Cui, Xinran Xu, Nini Jiang","doi":"10.5603/gpl.103660","DOIUrl":null,"url":null,"abstract":"Objectives: We investigated the correlation of plasma Afamin levels with gestational diabetes mellitus (GDM) during pregnancy and assessed its predictive value for the risk and prognosis of GDM.Material and methods: A total of 993 pregnant women were included in this nested case-control study. The fasting blood samples in their first trimester were collected. Ninety-one women were diagnosed with GDM, and they were subdivided into insulin treatment group (Group A1, 30 cases) and non-insulin treatment group (Group A2, 61 cases) according to whether they needed to treat with insulin. Another 91 pregnant women with normal glucose tolerance were as the control group (NC group). The plasma and umbilical cord blood levels of Afamin were measured in the first and second trimesters using enzyme-linked immunosorbent assay (ELISA). The correlation of Afamin levels with GDM during pregnancy and its predictive value were assessed.Results: Plasma Afamin levels in both GDM groups (A1 and A2) were significantly higher than in the control group at all pregnancy stages (p < 0.01). Afamin levels in the second trimester were significantly higher in Group A1 than those in Group A2 (p < 0.05). Multivariate logistic regression identified that plasma Afamin levels in the first trimester (OR = 1.126, 95% CI: 1.032-1.228, p = 0.008) and in the second trimester (OR = 1.173, 95% CI: 1.092-1.259, P = 0.000) were the independent risk factors for GDM, along with insulin resistance index (OR = 1.62, 95% CI: 1.036-2.534, p = 0.034). ROC analysis showed optimal cut-off value of plasma Afamin was 65.90 mg/L in the first trimester (AUC = 0.858, sensitivity = 75.8%, specificity = 85.7%) and 85.09 mg/L in the second trimester (AUC = 0.874, sensitivity = 92.3%, specificity = 76.9%).Conclusions: Elevated plasma Afamin levels during the first and second trimesters are associated with GDM, supporting Afamin level as a potential biomarker for early GDM risk prediction.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ginekologia polska","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5603/gpl.103660","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: We investigated the correlation of plasma Afamin levels with gestational diabetes mellitus (GDM) during pregnancy and assessed its predictive value for the risk and prognosis of GDM.

Material and methods: A total of 993 pregnant women were included in this nested case-control study. The fasting blood samples in their first trimester were collected. Ninety-one women were diagnosed with GDM, and they were subdivided into insulin treatment group (Group A1, 30 cases) and non-insulin treatment group (Group A2, 61 cases) according to whether they needed to treat with insulin. Another 91 pregnant women with normal glucose tolerance were as the control group (NC group). The plasma and umbilical cord blood levels of Afamin were measured in the first and second trimesters using enzyme-linked immunosorbent assay (ELISA). The correlation of Afamin levels with GDM during pregnancy and its predictive value were assessed.

Results: Plasma Afamin levels in both GDM groups (A1 and A2) were significantly higher than in the control group at all pregnancy stages (p < 0.01). Afamin levels in the second trimester were significantly higher in Group A1 than those in Group A2 (p < 0.05). Multivariate logistic regression identified that plasma Afamin levels in the first trimester (OR = 1.126, 95% CI: 1.032-1.228, p = 0.008) and in the second trimester (OR = 1.173, 95% CI: 1.092-1.259, P = 0.000) were the independent risk factors for GDM, along with insulin resistance index (OR = 1.62, 95% CI: 1.036-2.534, p = 0.034). ROC analysis showed optimal cut-off value of plasma Afamin was 65.90 mg/L in the first trimester (AUC = 0.858, sensitivity = 75.8%, specificity = 85.7%) and 85.09 mg/L in the second trimester (AUC = 0.874, sensitivity = 92.3%, specificity = 76.9%).

Conclusions: Elevated plasma Afamin levels during the first and second trimesters are associated with GDM, supporting Afamin level as a potential biomarker for early GDM risk prediction.

查看原文本刊更多论文

妊娠期血浆维生素a与妊娠期糖尿病的关系。

目的：探讨妊娠期血浆Afamin水平与妊娠期糖尿病（GDM）的相关性，并评估其对GDM风险和预后的预测价值。材料与方法：本研究共纳入993例孕妇。采集她们妊娠早期的空腹血样。将91例确诊为GDM的女性根据是否需要胰岛素治疗分为胰岛素治疗组（A1组，30例）和非胰岛素治疗组（A2组，61例）。另设91例糖耐量正常的孕妇作为对照组（NC组）。采用酶联免疫吸附试验（ELISA）测定妊娠早期和中期血浆和脐带血中Afamin的水平。评估Afamin水平与妊娠期GDM的相关性及其预测价值。结果：GDM组（A1和A2）妊娠各阶段血浆Afamin水平均显著高于对照组（p < 0.01）。妊娠中期A1组Afamin水平显著高于A2组（p < 0.05）。多因素logistic回归发现妊娠早期血浆Afamin水平（OR = 1.126, 95% CI: 1.032 ~ 1.228, p = 0.008）和妊娠中期血浆Afamin水平（OR = 1.173, 95% CI: 1.092 ~ 1.259, p = 0.000）与胰岛素抵抗指数（OR = 1.62, 95% CI: 1.036 ~ 2.534, p = 0.034）是GDM的独立危险因素。ROC分析显示，血浆Afamin最佳临界值在妊娠早期为65.90 mg/L (AUC = 0.858，敏感性= 75.8%，特异性= 85.7%)，在妊娠中期为85.09 mg/L （AUC = 0.874，敏感性= 92.3%，特异性= 76.9%）。结论：妊娠早期和中期血浆Afamin水平升高与GDM相关，支持Afamin水平作为早期GDM风险预测的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ginekologia polska

自引率

0.00%

发文量