Correlation analysis of ultrasound features with ER, PR, HER-2, P53, nuclear proliferation factor Ki-67, TOPIIa, and cytokeratin CK5/6 immunohistochemistry in non-mass infiltrating ductal carcinoma of the breast.

Abstract

Objectives: The goal is for investigating the correlation between ultrasound features and molecular pathological markers such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), tumor protein p53, nuclear proliferation factor Ki-67, DNA topoisomerase IIα (Topo II), and cytokeratin CK5/6 in non mass infiltrating ductal carcinoma of the breast.

Material and methods: A total of 125 sufferers with non mass infiltrating ductal carcinoma of the breast were included in the ultrasound images and immunohistochemical results. This study analyzed the characteristics of ultrasound images, including maximum cross-sectional diameter, morphology, peripheral hyperechoic halo, hair prick sign, and micro-calcification, as well as the positive expression of molecular pathological markers (ER, PR, HER-2, p53, Ki-67, Topo II, CK5/6); It uses statistical methods for evaluating the correlation between ultrasound features and molecular pathological markers.

Results: In 125 patients, the maximum cross-sectional diameter was markedly related to positive expression of CK5/6 (r = 0.176, p < 0.05), Ki-67 (r = 0.328, p < 0.05), and HER-2 (r = 0.468, p < 0.05). There is a marked relation between posterior echo attenuation and ER positivity (r = 0.096, p < 0.05) and Topo II positivity (r =-0.021, p < 0.05). However, there was no marked relation in morphology, peripheral hyperechoic halo, hairline sign, and micro-calcification with prognostic molecular pathological markers (p > 0.05).

Conclusions: This study found a marked relation in the maximum cross-sectional diameter of non mass infiltrating ductal carcinoma of the breast and the positive expression of CK5/6, Ki-67, and HER-2. This finding suggests that the maximum cross-sectional diameter may serve as a potential indicator for prognostic evaluation and is closely related to the expression of cytokeratin CK5/6, nuclear proliferation factor Ki-67, and HER-2 in tumors. Posterior echo attenuation is closely related to ER positive and Topo II expression. No significant correlation was observed between morphology, peripheral hyperechoic halo, hairline sign, and micro-calcification with prognostic molecular pathological markers. These results provide new insights for the prognosis evaluation of patients with non mass infiltrating ductal carcinoma of the breast and contribute to the development of individualized treatment strategies, but further research and validation are still needed.