Hiding in the kidney: a series of 13 lymphoid proliferations clinically mimicking renal carcinoma.

IF 3.1 3区 医学 Q1 PATHOLOGY
Jihoon William Lee, Marie E Perrone, Daniel E Sabath, Daniel W Lin, George R Schade, Funda Vakar-Lopez, Maria Tretiakova
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引用次数: 0

Abstract

Masses are commonly detected in the kidneys either as incidental findings or upon workup of urinary symptoms on an initial presentation. We describe a large series of rare cases in which individuals presented with symptoms or imaging findings of kidney masses concerning for primary carcinoma of renal cell or urothelial origin but were found on pathological analysis to be lymphomas or atypical lymphoid proliferations, with or without an accompanying renal malignancy. These mass lesions, including some unique mimics of renal carcinomas such as reactive follicular hyperplasia and IgG4-related disease primary to the kidney, are all lymphoid kidney proliferations from a single institution. Herein, we demonstrate the need for consideration of lymphoid abnormalities in the diagnosis of renal masses, which can affect further workup and management. We also review the differential diagnosis of primary renal masses originating from neoplastic and non-neoplastic lymphoid disorders.

隐藏在肾脏:一系列的13淋巴样增生临床模拟肾癌。
通常在肾脏中发现肿块,可能是偶然发现的,也可能是初次出现泌尿系统症状时的检查结果。我们描述了大量罕见病例,其中个体表现出与原发性肾细胞癌或尿路上皮癌有关的肾脏肿块的症状或影像学表现,但病理分析发现是淋巴瘤或非典型淋巴样增生,伴或不伴肾恶性肿瘤。这些肿块病变,包括一些独特的肾癌模拟,如反应性滤泡增生和原发性肾igg4相关疾病,都是来自单一机构的淋巴样肾增生。在此,我们证明在诊断肾肿块时需要考虑淋巴异常,这可能会影响进一步的检查和管理。我们也回顾了原发性肾肿块起源于肿瘤和非肿瘤淋巴系统疾病的鉴别诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Virchows Archiv
Virchows Archiv 医学-病理学
CiteScore
7.40
自引率
2.90%
发文量
204
审稿时长
4-8 weeks
期刊介绍: Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.
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