Saline-based modified del Nido cardioplegia versus multidose St. Thomas cardioplegia in canine mitral valve repair: A randomized controlled trial.

IF 1.3 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary Surgery Pub Date : 2025-06-09 DOI:10.1111/vsu.14278

Kentaro Kurogochi, Arane Takahashi, Yasuyuki Nii, Ayaka Chen, Masako Nishiyama, Shimon Furusato, Hiroshi Sugiya, Masami Uechi

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引用次数: 0

Abstract

Objective: To compare the utility of a saline-based modified del Nido (mDN) cardioplegia solution with a conventional institutional technique (multidose St. Thomas blood cardioplegia) for mitral valve repair (MVR) in dogs.

Study design: Prospective, randomized, open-label trial.

Animals: Forty client-owned dogs with myxomatous mitral valve disease (stage B2 and C) eligible for MVR were divided into control and modified mDN groups.

Methods: Cardioplegia was induced in the control group using 50% blood containing St. Thomas solution every 10 min. In the mDN group, a cardioplegia solution containing 20% blood was administered once or when required. As the primary outcome, serum cardiac troponin I levels were compared 12 h postoperatively between the groups. The other clinical findings were evaluated as secondary outcomes.

Results: Troponin levels 12 h after surgery were a median of 27.8 ng/mL (interquartile range, 15.1-43.2) in the control group and 19.4 ng/mL (15.2-33.6) in the mDN group (p = .478). The sinus rhythm recovery time following aortic cross-clamp removal was 362 s (103-995) in the control group and 60 s (44-605) in the mDN group (p = .027). The total amount of crystalloid cardioplegia solution required was 12.6 mL/kg (11.3-15.0) in the control group and 23.6 mL/kg (18.0-35.1) in the mDN group (p < .001).

Conclusion: Cardiac troponin I levels did not show differences between the groups. The saline-based mDN cardioplegia facilitated earlier sinus rhythm recovery.

Clinical significance: Saline-based mDN cardioplegia may be a viable alternative for canine MVR.

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在犬二尖瓣修复中，基于盐的改良德尔尼多心脏截止剂与多剂量圣托马斯心脏截止剂：一项随机对照试验。

目的：比较盐基改良德尔尼多（mDN）停搏液与常规机构技术（多剂量圣托马斯血液停搏）在犬二尖瓣修复（MVR）中的应用效果。研究设计：前瞻性、随机、开放标签试验。动物：40只符合MVR条件的二尖瓣黏液瘤病犬（B2期和C期）分为对照组和改良mDN组。方法：对照组采用50%血含圣托马斯液每10 min诱导心脏骤停。在mDN组中，一次或在需要时给予含20%血液的停搏液。作为主要终点，比较两组术后12小时血清心肌肌钙蛋白I水平。其他临床表现被评价为次要结果。结果：术后12 h，对照组肌钙蛋白水平中位数为27.8 ng/mL（四分位数范围15.1 ~ 43.2），mDN组为19.4 ng/mL (15.2 ~ 33.6) （p = 0.478）。去除主动脉交叉夹后，对照组窦性心律恢复时间为362 s (103-995)， mDN组为60 s(44-605)，差异有统计学意义（p = 0.027）。对照组和mDN组心脏停搏液总需水量分别为12.6 mL/kg（11.3 ~ 15.0）和23.6 mL/kg (18.0 ~ 35.1) (p)。以盐为基础的mDN心脏骤停促进早期窦性心律恢复。临床意义：基于盐的mDN心脏截瘫可能是犬MVR的可行选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Veterinary Surgery 农林科学-兽医学

CiteScore

3.40

自引率

22.20%

发文量

162

审稿时长

8-16 weeks

期刊介绍： Veterinary Surgery, the official publication of the American College of Veterinary Surgeons and European College of Veterinary Surgeons, is a source of up-to-date coverage of surgical and anesthetic management of animals, addressing significant problems in veterinary surgery with relevant case histories and observations. It contains original, peer-reviewed articles that cover developments in veterinary surgery, and presents the most current review of the field, with timely articles on surgical techniques, diagnostic aims, care of infections, and advances in knowledge of metabolism as it affects the surgical patient. The journal places new developments in perspective, encompassing new concepts and peer commentary to help better understand and evaluate the surgical patient.