Targeting FSH for osteoporosis, obesity, and Alzheimer's disease.

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2025-06-05 DOI:10.1016/j.molmed.2025.05.001

Funda Korkmaz, Judit Gimenez-Roig, Farhath Sultana, Victoria Laurencin, Fasilet Sen, Liam Cullen, Steven Sims, Anusha Pallapati, Satish Rojekar, Guzel Burganova, Georgii Pevnev, Uliana Cheliadinova, Darya Vasilyeva, Ofer Moldavski, Tal Frolinger, Anisa Gumerova, Orly Barak, Vitaly Ryu, Daria Lizneva, Keqiang Ye, Anne Schafer, Clifford J Rosen, Tony Yuen, Se-Min Kim, Mone Zaidi

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引用次数: 0

Abstract

Follicle-stimulating hormone (FSH), traditionally known for regulating gonadal development, maturation, and estrogen secretion, has now been implicated in regulating fat and bone metabolism and cognition. Preclinical evidence from genetic and pharmacological studies in rodent models, combined with human data from population-based observations, genetic studies, and a limited number of interventional trials, supports the notion of independent effects of FSH on the skeleton, fat, and brain. This evolving understanding of the nonreproductive roles of FSH presents potential therapeutic opportunities to mitigate age-related health challenges, which include osteoporosis, obesity, cardiovascular risk, and dementia. This review summarizes the current knowledge on the interplay between pituitary-derived FSH and peripheral and central tissues, as well as recent progress in therapeutic development.

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针对骨质疏松，肥胖和阿尔茨海默病的FSH。

卵泡刺激素（FSH），传统上被认为是调节性腺发育、成熟和雌激素分泌，现在被认为与调节脂肪和骨骼代谢和认知有关。来自啮齿动物模型的遗传和药理学研究的临床前证据，结合基于人群的观察、遗传研究和有限数量的干预性试验的人类数据，支持FSH对骨骼、脂肪和大脑的独立作用的概念。对卵泡刺激素非生殖作用的不断发展的理解为减轻与年龄相关的健康挑战提供了潜在的治疗机会，包括骨质疏松症、肥胖、心血管风险和痴呆。本文综述了目前关于垂体源性卵泡刺激素与外周和中枢组织相互作用的知识，以及治疗进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.