{"title":"Neural mechanism of dopamine modulating singing related behavior in songbirds: an updated review.","authors":"Linghua Zhong, Weiting Li, Mengjiao Liu, Wei Sun, Zhibin Liu, Songhua Wang","doi":"10.7717/peerj.19500","DOIUrl":null,"url":null,"abstract":"<p><p>Similar to human language, songbird singing is a complex motor skill learning behavior that is regulated by an interconnected network of neural nuclei in the brain. This network of nuclei demonstrates structural homology with human vocal control-related brain regions and shares common regulatory mechanisms for vocal learning. As an important neurotransmitter, dopamine plays a key role in the learning and maintenance of songbirds' singing behavior. Studies have demonstrated that the dopaminergic system plays a critical role in regulating the plasticity of singing via the midbrain dopamine pathway, which projects to the song control circuit. Novel experimental techniques, such as optogenetic circuit manipulation and neural activity monitoring, have significantly advanced our understanding of the cellular and synaptic mechanisms underlying vocalization behavior of dopamine effects. This review offers an updated insight into the neural mechanisms by which dopamine modulates singing-related behavior, along with future prospects for utilizing dopamine in the treatment of speech-related disorders.</p>","PeriodicalId":19799,"journal":{"name":"PeerJ","volume":"13 ","pages":"e19500"},"PeriodicalIF":2.4000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145779/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PeerJ","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.7717/peerj.19500","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Similar to human language, songbird singing is a complex motor skill learning behavior that is regulated by an interconnected network of neural nuclei in the brain. This network of nuclei demonstrates structural homology with human vocal control-related brain regions and shares common regulatory mechanisms for vocal learning. As an important neurotransmitter, dopamine plays a key role in the learning and maintenance of songbirds' singing behavior. Studies have demonstrated that the dopaminergic system plays a critical role in regulating the plasticity of singing via the midbrain dopamine pathway, which projects to the song control circuit. Novel experimental techniques, such as optogenetic circuit manipulation and neural activity monitoring, have significantly advanced our understanding of the cellular and synaptic mechanisms underlying vocalization behavior of dopamine effects. This review offers an updated insight into the neural mechanisms by which dopamine modulates singing-related behavior, along with future prospects for utilizing dopamine in the treatment of speech-related disorders.
期刊介绍：
PeerJ is an open access peer-reviewed scientific journal covering research in the biological and medical sciences. At PeerJ, authors take out a lifetime publication plan (for as little as $99) which allows them to publish articles in the journal for free, forever. PeerJ has 5 Nobel Prize Winners on the Board; they have won several industry and media awards; and they are widely recognized as being one of the most interesting recent developments in academic publishing.
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