Relation of time in range to severity of coronary artery disease in patients with type 2 diabetes: A cross-sectional study.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Open Medicine Pub Date : 2025-06-04 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1158

Weiguo Ma, Jinfeng Li, Xiaojuan Shao, Xiaohong Yin, Chuanqing Xie, Fenfen Wang, Ya Li

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引用次数: 0

Abstract

Background: Despite the high prevalence and serious clinical implications of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM), the relationship between glycemic control and CAD is usually overlooked. This study aimed to explore the relationship between time in range (TIR), a surrogate marker for glycemic control, and CAD in patients with T2DM.

Methods: Overall, 334 patients with T2DM were included and analyzed in this cross-sectional study. The presence of CAD was determined angiographically and the Gensini score was applied to evaluate CAD severity. TIR was calculated from sensor glucose from continuous glucose monitoring. Multivariable-adjusted logistic regression analysis was used to evaluate the relationship between TIR and CAD presence.

Results: T2DM with CAD had significantly lower TIR than those without (75.68 ± 13.74 vs 66.12 ± 11.87, P < 0.01). Moreover, TIR was correlated with CAD severity as indicated by the Gensini score. Multivariable-adjusted logistic regression analysis indicated that a higher TIR was an independent protective factor for CAD in patients with T2DM (OR = 0.919, 95% CI: 0.896-0.942).

Conclusion: TIR is significantly and independently related to CAD severity in T2DM patients. Thus, TIR could be a promising biomarker for the noninvasive assessment of CAD presence and severity in T2DM.

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2型糖尿病患者冠状动脉病变严重程度与时间范围的关系：一项横断面研究

背景：尽管冠状动脉疾病（CAD）在2型糖尿病（T2DM）患者中发病率高且具有严重的临床意义，但血糖控制与CAD之间的关系通常被忽视。本研究旨在探讨T2DM患者血糖控制的替代指标TIR与CAD之间的关系。方法：本横断面研究共纳入334例T2DM患者。通过血管造影确定冠心病的存在，并应用Gensini评分评估冠心病的严重程度。TIR由连续血糖监测的传感器葡萄糖计算。采用多变量调整logistic回归分析评估TIR与CAD存在的关系。结果：T2DM合并CAD的TIR明显低于未合并CAD的T2DM（75.68±13.74 vs 66.12±11.87,P < 0.01）。此外，TIR与CAD严重程度相关，如Gensini评分所示。多变量校正logistic回归分析显示，较高的TIR是T2DM患者冠心病的独立保护因素（OR = 0.919, 95% CI: 0.896-0.942）。结论：T2DM患者的TIR与冠心病严重程度有显著且独立的相关性。因此，TIR可能是一种有前景的生物标志物，用于无创评估2型糖尿病中CAD的存在和严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.