Lipoic acid in metabolic dysfunction-associated steatotic liver disease: a review.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2025-06-07 DOI:10.1186/s12986-025-00954-9

Fangli Liu, Jingjing Lv, Yuanyuan Chen, Linfeng Wang, Zhuoxin Liu, Xingke Li

{"title":"Lipoic acid in metabolic dysfunction-associated steatotic liver disease: a review.","authors":"Fangli Liu, Jingjing Lv, Yuanyuan Chen, Linfeng Wang, Zhuoxin Liu, Xingke Li","doi":"10.1186/s12986-025-00954-9","DOIUrl":null,"url":null,"abstract":"<p><p>The incidence and prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver disease characterized by hepatic steatosis without substantial alcohol consumption, are rapidly increasing worldwide. Liver cirrhosis and cancer are relatively common in MASLD patients. Therefore, it is essential to take proactive measures in preventing its onset or initiating prompt treatment. However, there is a lack of approved medications for effectively treating this ailment. Lipoic acid (LA), a compound with antioxidant, insulin-sensitization, anti-inflammatory, and prooxidant activities, has been proven to inhibit lipid deposition. Many studies have shown that supplementation of LA can alleviate MASLD. Therefore, the latest evidence on the relationship between LA and MASLD is presented in this review. The effect of LA on the accumulation of fat in the liver is emphasized following different diet models (normal, high fat, high fructose, choline deficiency) and other models (gene mutation, diabetes), with the main mechanisms from mitochondrial function to inflammation and oxidative stress being summarized. LA possesses excellent preventive effects on MASLD, which can provide new opportunities for clinical research.</p>","PeriodicalId":19196,"journal":{"name":"Nutrition & Metabolism","volume":"22 1","pages":"56"},"PeriodicalIF":3.9000,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145643/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12986-025-00954-9","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

The incidence and prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver disease characterized by hepatic steatosis without substantial alcohol consumption, are rapidly increasing worldwide. Liver cirrhosis and cancer are relatively common in MASLD patients. Therefore, it is essential to take proactive measures in preventing its onset or initiating prompt treatment. However, there is a lack of approved medications for effectively treating this ailment. Lipoic acid (LA), a compound with antioxidant, insulin-sensitization, anti-inflammatory, and prooxidant activities, has been proven to inhibit lipid deposition. Many studies have shown that supplementation of LA can alleviate MASLD. Therefore, the latest evidence on the relationship between LA and MASLD is presented in this review. The effect of LA on the accumulation of fat in the liver is emphasized following different diet models (normal, high fat, high fructose, choline deficiency) and other models (gene mutation, diabetes), with the main mechanisms from mitochondrial function to inflammation and oxidative stress being summarized. LA possesses excellent preventive effects on MASLD, which can provide new opportunities for clinical research.

查看原文本刊更多论文

硫辛酸与代谢功能障碍相关的脂肪变性肝病的研究进展

代谢功能障碍相关的脂肪变性肝病（MASLD）是一种慢性肝病，其发病率和流行率在世界范围内迅速增加，其特征是肝脏脂肪变性而非大量饮酒。肝硬化和癌症在MASLD患者中相对常见。因此，必须采取积极的措施预防其发生或开始及时治疗。然而，目前还缺乏有效治疗这种疾病的药物。硫辛酸（LA）是一种具有抗氧化、胰岛素增敏、抗炎和促氧化活性的化合物，已被证明可以抑制脂质沉积。许多研究表明，补充LA可以缓解MASLD。因此，本文综述了LA与MASLD之间关系的最新证据。通过不同的饮食模型（正常、高脂、高果糖、胆碱缺乏）和其他模型（基因突变、糖尿病），强调了LA对肝脏脂肪积累的影响，并总结了从线粒体功能到炎症和氧化应激的主要机制。LA对MASLD具有良好的预防作用，为临床研究提供了新的契机。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.