SCUBE-1 Levels and Their Relationship with Endothelial Dysfunction in Obstructive Sleep Apnea Syndrome Patients.

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2025-06-03 eCollection Date: 2025-01-01 DOI:10.2147/NSS.S509757

Nevin Fazlıoğlu, Cihan Aydın, Aykut Demirkıran, Demet Özkaramanlı Gür, Ahsen Yılmaz, Aliye Çelikkol

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引用次数: 0

Abstract

Objective: Obstructive sleep apnea syndrome (OSAS) increases the risk of vascular dysfunction by causing hypoxemia due to recurrent obstructions in the upper airway. This can put pressure on the vasculature and impair endothelial function. SCUBE-1 gains importance in OSAS as a biomarker that may reflect this dysfunction. We focused in this study on the association between levels of SCUBE-1 and endothelial dysfunction in patients suffering from OSAS.

Methods: A study population of 75 individuals participated in the study. Participants were categorized as normal (n=18), mild OSAS (n=22), moderate OSAS (n=19) and severe OSAS (n=16) according to polysomnography findings. Evaluation parameters included SCUBE-1 levels, polysomnography measurements, flow-mediated dilatation (FMD), carotid intima-media thickness (CIMT), and comprehensive laboratory analyses.

Results: SCUBE-1 levels were significantly higher in the severe OSAS group (15.8 ± 4.2 ng/mL, p<0.001). SCUBE-1 showed a moderate negative correlation with FMD (r = -0.248, p < 0.001) and a significant negative correlation with CIMT (r = -0.512, p < 0.001). ROC analysis demonstrated good diagnostic accuracy (AUC: 0.871, 95% CI: 0.797-0.945) for SCUBE-1 in identifying severe OSAS.

Conclusion: OSAS severity correlates with the rise in SCUBE-1 levels, and this biomarker may serve as an important attribute in profiling endothelial dysfunction. SCUBE-1 can indeed be an effective biomarker to identify subtle changes in the vascular biology of OSAS patients and aid early interventions.

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阻塞性睡眠呼吸暂停综合征患者SCUBE-1水平及其与内皮功能障碍的关系

目的：阻塞性睡眠呼吸暂停综合征（OSAS）由于上呼吸道反复阻塞而引起低氧血症，从而增加血管功能障碍的风险。这会对血管系统造成压力，损害内皮功能。scub -1在OSAS中作为一种可能反映这种功能障碍的生物标志物而变得重要。在这项研究中，我们关注的是OSAS患者中SCUBE-1水平与内皮功能障碍之间的关系。方法：研究人群75人参与研究。根据多导睡眠图结果，将参与者分为正常（n=18）、轻度OSAS （n=22）、中度OSAS （n=19）和重度OSAS （n=16）。评估参数包括SCUBE-1水平、多导睡眠图测量、血流介导扩张（FMD）、颈动脉内膜-中膜厚度（CIMT）和综合实验室分析。结果：重度OSAS组scbe -1水平显著升高（15.8±4.2 ng/mL）。结论：OSAS严重程度与scbe -1水平升高相关，该生物标志物可能是分析内皮功能障碍的重要属性。SCUBE-1确实可以作为一种有效的生物标志物来识别OSAS患者血管生物学的细微变化，并有助于早期干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.