Secondary metabolites from Pometia pinnata leaves.

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-06-07 DOI:10.1080/14786419.2025.2514736

Isti Istiqamah, Herliana Herliana, Agil Fadilah, Aih Diniresna, Rizki Fitriani, Muhamad Insanu, Elvira Hermawati, Nizar Happyana

引用次数: 0

Abstract

A new hederagenin glycoside, named pometin B [3-O-(5'''-O-acetyl-α-L-arabinofuranosyl)-(1'''→3')-[α-L-rhamnopyranosyl-(1''→2')]-β-L-arabinopyranosyl hederagenin] (1), was isolated from Pometia pinnata leaves along with known compounds, including stigmasterol-3-O-α-glucoside (2), kaempferol-3-O-α-rhamnoside (3), quercetin-3-O-α-rhamnoside (4), and proanthocyanidin A2 (5). The chemical structures of these compounds were confirmed through detailed analysis of 1D and 2D NMR spectra, supported by mass spectrometry data. The identities of known compounds were further verified by comparison with the corresponding data in the literature. Compound 1 exhibited notable cytotoxic activity against the MCF7 cell line with the IC₅₀ value of 3.69 μg/mL. Compounds 3-5 showed significant antioxidant and alpha-glucosidase inhibitory activities.

查看原文本刊更多论文

石榴树叶次生代谢物。

从石榴叶中分离得到了一种新的柚皮苷苷B [3- o -(5'' - o -乙酰基-α- l- arabinofuranosyl)-(1‘’→3')-[α-L-rhamnopyranosyl-(1‘’→2')]-β- l- arabinopyranosyl hederagenin](1)，与已知化合物包括豆甾醇-3- o -α-鼠李糖苷(2)、山奈酚-3- o -α-鼠李糖苷(3)、槲皮素-3- o -α-鼠李糖苷(4)和原花青素A2(5)。这些化合物的化学结构通过详细的一维和二维核磁共振谱分析得到证实，并得到质谱数据的支持。通过与文献中相应数据的比较，进一步验证了已知化合物的性质。化合物1对MCF7细胞株具有显著的细胞毒活性，IC50值为3.69 μg/mL。化合物3 ~ 5具有显著的抗氧化和α -葡萄糖苷酶抑制活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.