Association between Acute Kidney Injury and Dementia: A Multi-Database Cohort Study.

IF 3.2 4区医学 Q1 UROLOGY & NEPHROLOGY

Kidney Diseases Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI:10.1159/000545963

Zhixin Guo, Caoxiang She, Yaduan Lin, Shiyu Zhou, Fan Luo, Lisha Cao, Yinfang Sun, Ruixuan Chen, Mingzhen Pang, Xian Shao, Sheng Nie

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引用次数: 0

Abstract

Introduction: With the aging of population, dementia has emerged as a major public health concern, imposing a heavy society burden. However, the relationship between acute kidney injury (AKI) and the risk of dementia remains uncertain.

Methods: A total of 1,256,756 participants from the China Renal Data System (CRDS) database and 492,250 individuals from the UK biobank (UKB) dataset were included in the study. The study investigated the associations between AKI and the onset of dementia. The exposure of interest was AKI. The outcome in both the CRDS and UKB cohorts was dementia.

Results: The CRDS cohort identified 7,878 patients with new-onset dementia, while the UKB recorded 9,926 dementia cases during follow-up. AKI showed a significant association with the risk of dementia in both the CRDS (adjusted HR: 1.22; 95% confidence interval [CI]: 1.13-1.30, p < 0.001) and UKB cohorts (adjusted HR: 1.64; 95% CI 1.29-1.98, p = 0.005). In the CRDS cohort, patients with more severe AKI (stage 2-3 AKI) (aHR: 1.25; 95% CI 1.09-1.42, p = 0.008) exhibited a higher adjusted HR for dementia compared to those at AKI stage 1 (aHR: 1.21; 95% CI 1.11-1.30, p < 0.001). The association between AKI and dementia remained consistent across different subgroups in both cohorts.

Conclusion: Our findings demonstrated that AKI was associated with an elevated risk of all-cause dementia. Consequently, patients with history of AKI episodes necessitate vigilant monitoring for prevention of dementia.

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急性肾损伤与痴呆之间的关系：一项多数据库队列研究。

导言：随着人口老龄化，痴呆症已成为一个重大的公共卫生问题，给社会造成了沉重的负担。然而，急性肾损伤（AKI）与痴呆风险之间的关系仍不确定。方法：来自中国肾脏数据系统（CRDS）数据库的1,256,756名参与者和来自英国生物银行（UKB）数据集的492,250名参与者被纳入研究。该研究调查了AKI与痴呆发病之间的关系。感兴趣的暴露是AKI。CRDS和UKB的结果都是痴呆。结果：CRDS队列确定了7878例新发痴呆患者，而UKB在随访期间记录了9926例痴呆病例。在两项CRDS中，AKI均与痴呆风险显著相关(调整HR: 1.22；95%可信区间[CI]: 1.13-1.30, p < 0.001)和UKB队列(校正HR: 1.64；95% CI 1.29-1.98, p = 0.005)。在CRDS队列中，重度AKI（2-3期AKI）患者(aHR: 1.25；95% CI 1.09-1.42, p = 0.008)与AKI 1期相比，痴呆的调整HR更高(aHR: 1.21；95% CI 1.11-1.30, p < 0.001)。AKI和痴呆之间的关联在两个队列的不同亚组中保持一致。结论：我们的研究结果表明，AKI与全因痴呆的风险升高有关。因此，有AKI发作史的患者需要警惕监测以预防痴呆。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney Diseases UROLOGY & NEPHROLOGY-

CiteScore

6.00

自引率

2.70%

发文量

审稿时长

27 weeks

期刊介绍： ''Kidney Diseases'' aims to provide a platform for Asian and Western research to further and support communication and exchange of knowledge. Review articles cover the most recent clinical and basic science relevant to the entire field of nephrological disorders, including glomerular diseases, acute and chronic kidney injury, tubulo-interstitial disease, hypertension and metabolism-related disorders, end-stage renal disease, and genetic kidney disease. Special articles are prepared by two authors, one from East and one from West, which compare genetics, epidemiology, diagnosis methods, and treatment options of a disease.