Are anxious Mondays associated with HPA-axis dysregulation? A longitudinal study of older adults in England

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-06-05 DOI:10.1016/j.jad.2025.119611

Tarani Chandola , Wanying Ling , Patrick Rouxel

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引用次数: 0

Abstract

Objective

To investigate whether the association between perceived anxiety and HPA-axis dysregulation is greater on Mondays than on other days of the week.

Design

Observational study with longitudinal data.

Setting

England.

Participants

3511 adults aged 50 years and older living in England from 2012 to 2013 participating at wave 6 of the English Longitudinal Study of Ageing.

Main outcome measures

Levels of hair cortisol and total glucocorticoid production.

Results

This study found strong evidence for an association between reporting anxiety on Mondays and HPA-axis dysregulation. At the 90th quantile of the cortisol distribution, older adults who felt anxious on Mondays had 23 % higher cortisol levels in the hair samples collected up to 2 months later than did their peers who reported anxiety on other days. There were no significant differences in cortisol levels or total glucocorticoid production by feelings of anxiety on other days of the week. The anxious Monday association with HPA-axis dysregulation measured subsequently was evident among both working and nonworking older adults, with no reduction in the association among those not at work. Around three-quarters of the differences in HPA-axis dysregulation between Mondays and other days was due to the differential effects of the characteristics of older adults who reported feeling anxious on Mondays.

Conclusions

HPA-axis dysregulation is pronounced among older adults who report anxiety on Mondays. This association was observed regardless of employment status, suggesting that both working and nonworking older adults are at risk of HPA-axis dysregulation associated with the start of the week.

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周一焦虑与hpa轴失调有关吗？一项对英国老年人的纵向研究。

目的：探讨感知焦虑与hpa轴失调在周一的相关性是否大于一周中的其他日子。设计：纵向数据的观察性研究。设置:英格兰。参与者：3511名年龄在50 岁及以上的成年人，2012年至2013年居住在英格兰，参加了英国老龄化纵向研究的第6轮。主要观察指标：毛发皮质醇和总糖皮质激素分泌水平。结果：本研究发现了周一报告焦虑与hpa轴失调之间存在关联的有力证据。在皮质醇分布的第90分位数，在周一感到焦虑的老年人在收集的头发样本中的皮质醇水平比在其他日子报告焦虑的同龄人高出23% %，时间长达2 个月。在一周的其他日子里，焦虑的感觉在皮质醇水平或总糖皮质激素分泌方面没有显著差异。随后测量的焦虑星期一与hpa轴失调的关系在工作和不工作的老年人中都很明显，而在不工作的老年人中没有减少这种关系。周一和其他日子之间hpa轴失调的差异中，约有四分之三是由于在周一感到焦虑的老年人的特征不同造成的。结论：hpa轴失调在周一报告焦虑的老年人中是明显的。无论就业状况如何，这种关联都被观察到，这表明工作和非工作的老年人在一周开始时都有hpa轴失调的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.