Control measures for neglected tropical diseases: vaccine updates.

IF 5.5 3区医学 Q1 IMMUNOLOGY

Expert Review of Vaccines Pub Date : 2025-12-01 Epub Date: 2025-06-14 DOI:10.1080/14760584.2025.2517712

Vivek P Chavda, Suneetha Vuppu, Toshika Mishra, Nikita Sharma, Sathvika Kamaraj, Shatakshi Mishra, Bhumi Sureshbhai, John Matsoukas, Vasso Apostolopoulos

{"title":"Control measures for neglected tropical diseases: vaccine updates.","authors":"Vivek P Chavda, Suneetha Vuppu, Toshika Mishra, Nikita Sharma, Sathvika Kamaraj, Shatakshi Mishra, Bhumi Sureshbhai, John Matsoukas, Vasso Apostolopoulos","doi":"10.1080/14760584.2025.2517712","DOIUrl":null,"url":null,"abstract":"Introduction: Infectious diseases like neglected tropical diseases (NTDs) have seen a rapid surge in recent times, threatening public health. These diseases impose a significant global health burden, affecting individuals, particularly in tropical locations characterized by low-income populations. The comprehensive compilation of NTDs includes an array of bacterial, viral, and parasitic infections. The prioritization of 20-NTD action plans in 2020 was undertaken by the WHO to acknowledge their importance. Infections such as leishmaniasis, schistosomiasis, and human African trypanosomiasis exhibit high rates of mortality. This highlights the pressing need for collaborative initiatives aimed at addressing these diseases and minimizing their detrimental impact on susceptible populations.Areas covered: The etiology, types of NTDs, and management strategies, particularly vaccinations are discussed. The limitations of the available vaccines and the scope of development of novel formulations are also covered.Expert opinion: The emergence of vaccines for NTDs poses significant challenges, mostly arising from the complex developmental phases of diverse diseases, inadequate resources for research, minimal involvement from the pharmaceutical industry, and the wide spectrum of infections, impeding vaccine development. Advancements in technology have improved vaccine quality, which could lead to the development of personalized vaccines tailored to individual susceptibility to specific NTD pathogens.","PeriodicalId":12326,"journal":{"name":"Expert Review of Vaccines","volume":" ","pages":"535-555"},"PeriodicalIF":5.5000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Vaccines","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14760584.2025.2517712","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Infectious diseases like neglected tropical diseases (NTDs) have seen a rapid surge in recent times, threatening public health. These diseases impose a significant global health burden, affecting individuals, particularly in tropical locations characterized by low-income populations. The comprehensive compilation of NTDs includes an array of bacterial, viral, and parasitic infections. The prioritization of 20-NTD action plans in 2020 was undertaken by the WHO to acknowledge their importance. Infections such as leishmaniasis, schistosomiasis, and human African trypanosomiasis exhibit high rates of mortality. This highlights the pressing need for collaborative initiatives aimed at addressing these diseases and minimizing their detrimental impact on susceptible populations.

Areas covered: The etiology, types of NTDs, and management strategies, particularly vaccinations are discussed. The limitations of the available vaccines and the scope of development of novel formulations are also covered.

Expert opinion: The emergence of vaccines for NTDs poses significant challenges, mostly arising from the complex developmental phases of diverse diseases, inadequate resources for research, minimal involvement from the pharmaceutical industry, and the wide spectrum of infections, impeding vaccine development. Advancements in technology have improved vaccine quality, which could lead to the development of personalized vaccines tailored to individual susceptibility to specific NTD pathogens.

查看原文本刊更多论文

被忽视的热带病控制措施：疫苗更新。

导言：近年来，被忽视的热带病等传染病迅速增加，威胁着公众健康。这些疾病对个人造成重大的全球健康负担，特别是在以低收入人口为特征的热带地区。被忽视热带病的综合汇编包括一系列细菌、病毒和寄生虫感染。世卫组织确定了2020年20个传染性疾病行动计划的优先顺序，以承认其重要性。诸如利什曼病、血吸虫病和非洲人类锥虫病等传染病的死亡率很高。这突出表明迫切需要采取合作行动，以对付这些疾病并尽量减少它们对易感人群的有害影响。涵盖领域：讨论了被忽视热带病的病因、类型和管理策略，特别是疫苗接种。还讨论了现有疫苗的局限性和开发新配方的范围。专家意见：被忽视热带病疫苗的出现带来了重大挑战，主要是由于各种疾病的复杂发展阶段、研究资源不足、制药业极少参与以及感染范围广泛，阻碍了疫苗的开发。技术的进步提高了疫苗的质量，这可能导致开发针对个人对特定NTD病原体易感性的个性化疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Expert Review of Vaccines 医学-免疫学

CiteScore

9.10

自引率

3.20%

发文量

136

审稿时长

4-8 weeks

期刊介绍： Expert Review of Vaccines (ISSN 1476-0584) provides expert commentary on the development, application, and clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines for defence against bioterrorism. All articles are subject to rigorous peer-review. The vaccine field has been transformed by recent technological advances, but there remain many challenges in the delivery of cost-effective, safe vaccines. Expert Review of Vaccines facilitates decision making to drive forward this exciting field.