Toll-like receptor-4 in the fish immune system

IF 2.4 3区农林科学 Q1 FISHERIES

Developmental and comparative immunology Pub Date : 2025-06-04 DOI:10.1016/j.dci.2025.105400

Chunxia Li , Xubin Zheng , Mengna Chang , Qinyao Tian , Zhi He , Ziting Tang , Xiaojing Chen , Xiaoying Liu , Deying Yang , Taiming Yan

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Abstract

Toll-like receptors (TLRs) represent a critical class of protein molecules integral to nonspecific immunity (innate immunity), and serve as key mediators bridging between nonspecific and specific immune responses. As an important member of the TLR multigene family, toll-like receptor 4 (TLR4) holds particular significance due to its broad expression across various animal tissues and its pivotal roles in pathogen recognition, signal transduction, and the modulation of inflammatory responses. In aquaculture, Tlr4 has emerged as a promising target for the development of vaccines, immune enhancers, and adjuvants aimed at bolstering the health and disease resistance of aquatic animals, thereby reducing the reliance on antibiotics. To date, studies on Tlr4 primarily focused on its structural and functional properties, expression patterns, immune responses, and evolutionary dynamics. This review synthesizes current knowledge on the structural features, functions, regulatory mechanisms, and potential applications of Tlr4 in the immune system of fish, providing a foundational framework for advancing studies on fish immunity.

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鱼类免疫系统中的toll样受体-4。

toll样受体（TLRs）代表了非特异性免疫（先天免疫）不可或缺的一类关键蛋白质分子，并作为非特异性和特异性免疫应答之间的关键中介。toll样受体4 （toll-like receptor 4, TLR4）作为TLR多基因家族的重要成员，因其在多种动物组织中的广泛表达以及在病原体识别、信号转导和炎症反应调节中发挥的关键作用而具有特殊的意义。在水产养殖中，Tlr4已成为开发疫苗、免疫增强剂和佐剂的一个有希望的靶标，旨在增强水生动物的健康和抗病能力，从而减少对抗生素的依赖。迄今为止，对Tlr4的研究主要集中在其结构和功能特性、表达模式、免疫反应和进化动力学等方面。本文综述了Tlr4在鱼类免疫系统中的结构特征、功能、调控机制及潜在应用等方面的研究进展，为进一步开展鱼类免疫研究提供基础框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental and comparative immunology 医学-动物学

CiteScore

6.20

自引率

6.90%

发文量

206

审稿时长

49 days

期刊介绍： Developmental and Comparative Immunology (DCI) is an international journal that publishes articles describing original research in all areas of immunology, including comparative aspects of immunity and the evolution and development of the immune system. Manuscripts describing studies of immune systems in both vertebrates and invertebrates are welcome. All levels of immunological investigations are appropriate: organismal, cellular, biochemical and molecular genetics, extending to such fields as aging of the immune system, interaction between the immune and neuroendocrine system and intestinal immunity.