Targeting Metastasis: Exploring the Impact of Microbial Infections on Cancer Progression Through Innovative Biological Models.

IF 2.3 3区生物学 Q3 MICROBIOLOGY

Current Microbiology Pub Date : 2025-06-07 DOI:10.1007/s00284-025-04306-x

Mohamed A El-Tayeb

引用次数: 0

Abstract

Infectious diseases, particularly viral infections, pose a significant threat to human health by contributing to cancer progression and metastasis. This review presents a novel perspective on how advanced biological models such as organoids, organ-on-a-chip systems, spheroids, and 3D bioprinting bridge critical translational gaps in research. These models replicate human physiological processes, allowing for the investigation of molecular mechanisms and the evaluation of novel therapeutics. This review will explore the current state of advanced biological models used to study viral infections associated with metastasis to better understand how viral-induced changes impact tumor behavior and the implications for future treatment strategies.

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靶向转移：通过创新的生物学模型探索微生物感染对癌症进展的影响。

传染病，特别是病毒感染，通过促进癌症的进展和转移，对人类健康构成重大威胁。这篇综述提出了一个关于先进生物模型（如类器官、器官芯片系统、球体和3D生物打印）如何弥合研究中关键的转化差距的新视角。这些模型复制了人类生理过程，允许研究分子机制和评估新的治疗方法。本文将探讨用于研究与转移相关的病毒感染的先进生物学模型的现状，以更好地了解病毒诱导的变化如何影响肿瘤行为以及对未来治疗策略的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Microbiology 生物-微生物学

CiteScore

4.80

自引率

3.80%

发文量

380

审稿时长

2.5 months

期刊介绍： Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment. Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas: physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.