Correlation Analysis between Serum Uric Acid Levels and Bone Mineral Density in Children with Obesity.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-06-02 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S521357

Naijun Wan, Qian Zhang, Jin Zhang, Tian Zhang, Weijia Shi

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引用次数: 0

Abstract

Purpose: To investigate the relationship between serum uric acid (SUA) levels and bone mineral density (BMD) in children with obesity.

Methods: 229 children with obesity were included in the study, and their blood SUA, fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), calcium (Ca), phosphorus (P), 25-hydroxyvitamin D (25(OH)D) and other indicators were measured. Distal forearm BMD was assessed at the radius and ulna. Differences in these indicators were compared across different genders and age groups.

Results: BMD showed significant differences between genders and age groups. The BMD Z-score in the 6-9 years group was higher than that in the 10-12 years group for both boys (-0.13 ± 0.92 vs -1.27 ± 0.62, p = 0.000) and girls (0.68 ± 0.96 vs -0.03 ± 0.73, p = 0.001). Serum SUA levels in the 6-9 years group were lower than those in the 10-12 years group for both boys (345.9 ± 65.7 vs 415.39 ± 74.02, p = 0.000) and girls (338.33 ± 63.33 vs 368.61 ± 75.45, p = 0.047). SUA was negatively correlated with BMD in all age groups of boys and in the 6-9 years group of girls (p<0.05). Multiple linear regression analysis showed that after controlling for other factors affecting BMD, SUA remained significantly negatively correlated with BMD Z-scores (p < 0.001).

Conclusion: SUA is negatively correlated with BMD in children with obesity and is an independent factor affecting BMD. It may serve as a potential predictor of BMD in children with obesity.

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肥胖儿童血清尿酸水平与骨密度的相关性分析。

目的：探讨肥胖儿童血清尿酸（SUA）水平与骨密度（BMD）的关系。方法：选取229例肥胖儿童作为研究对象，测定其血SUA、空腹血糖（FPG）、糖化血红蛋白（HbAlc）、钙（Ca）、磷(P)、25-羟基维生素D （25(OH)D）等指标。在桡骨和尺骨处评估前臂远端骨密度。比较了这些指标在不同性别和年龄组之间的差异。结果：骨密度在性别、年龄组间存在显著差异。6-9岁组男孩（-0.13±0.92 vs -1.27±0.62,p = 0.000）和女孩（0.68±0.96 vs -0.03±0.73,p = 0.001） BMD Z-score均高于10-12岁组。6-9岁组男孩（345.9±65.7 vs 415.39±74.02,p = 0.000）和女孩（338.33±63.33 vs 368.61±75.45,p = 0.047）血清SUA水平均低于10-12岁组。在所有年龄组的男孩和6-9岁年龄组的女孩中，SUA与BMD呈负相关(p结论：SUA与肥胖儿童的BMD呈负相关，是影响BMD的独立因素。它可能作为肥胖儿童骨密度的潜在预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.