Traditional Chinese Medicine and Ferroptosis in Intracerebral Hemorrhage: A Potential Therapeutic Approach.

IF 5.1 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2025-06-04 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S513343

Hanying Xu, Jing Lu, Xiaolei Tang, Pengfei Li, Lei Wu, Jian Wang, Ying Zhang, Dongmei Zhang

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Abstract

Intracerebral hemorrhage (ICH) is a severe cerebrovascular disorder associated with high morbidity and mortality. Ferroptosis, a regulated form of cell death characterized by iron accumulation and lipid peroxidation, plays a critical role in secondary injury following ICH. Traditional Chinese Medicine (TCM) has demonstrated distinct therapeutic benefits in cerebrovascular disease, and emerging evidence suggests its potential to modulate ferroptosis. This review explores the therapeutic effects of TCM and TCM-based interventions for ICH, with a focus on their regulation of ferroptosis-related mechanisms. In ICH, ferroptosis is driven by disrupted iron metabolism, lipid peroxidation, oxidative stress, and neuroinflammation-key contributors to secondary brain injury. TCM interventions, including herbal medicines, active compounds, and acupuncture, may counteract these processes by restoring iron homeostasis and reducing oxidative stress, thereby improving neurological outcomes. Given the critical role of ferroptosis in ICH pathophysiology, TCM represents a promising avenue for targeting ferroptosis-related pathways and advancing therapeutic strategies.

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中药与脑出血铁下垂：一种潜在的治疗方法。

脑出血是一种严重的脑血管疾病，发病率和死亡率都很高。铁凋亡是一种以铁积累和脂质过氧化为特征的细胞死亡的调节形式，在脑出血后的继发性损伤中起关键作用。中医药在脑血管疾病中已显示出明显的治疗效果，新出现的证据表明其具有调节铁下垂的潜力。本文综述了中医及基于中医的干预措施对脑出血的治疗效果，重点探讨了其对铁衰相关机制的调节作用。在脑出血中，铁下垂是由铁代谢中断、脂质过氧化、氧化应激和神经炎症驱动的，这些都是继发性脑损伤的关键因素。中医干预，包括草药、活性化合物和针灸，可以通过恢复铁稳态和减少氧化应激来抵消这些过程，从而改善神经系统的预后。鉴于铁下垂在脑出血病理生理中的关键作用，中医药为靶向铁下垂相关途径和推进治疗策略提供了一条有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.