Association between sarcopenic obesity and the risk of knee osteoarthritis in the middle-aged and elderly Chinese population: A 7-year cohort study

IF 2.6 Q3 NUTRITION & DIETETICS
Xinyang Wang, Yubao Liu, Yucheng Lin, Yuanhao Liu, Linshu Guan, Jun Lu
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Abstract

Objective

To investigate the relationship between sarcopenic obesity and the risk of knee osteoarthritis (KOA) in middle-aged and elderly individuals.

Methods

This study utilized cohort data from the China Health and Retirement Longitudinal Study (CHARLS) database, focusing on middle-aged and elderly individuals without knee osteoarthritis in 2011. A total of 4299 participants aged over 45 who met the inclusion and exclusion criteria were included. Using overweight as the criterion for obesity, participants were divided into four groups: normal control, only overweight, only sarcopenia, and sarcopenic overweight. Cox proportional hazards models were employed for survival analysis, comparing the normal control group with the other three groups to assess their impact on the risk of developing knee osteoarthritis. Sensitivity analyses were conducted using sarcopenia obese and sarcopenia abdominal obesity to ensure the robustness of the results. Additionally, subgroup analyses were performed to explore the influence of different populations on the outcomes. Lastly, we investigated the association between probable sarcopenic obesity and KOA.

Results

Compared to the normal control group, the sarcopenic obesity group showed a significantly increased risk of KOA Hazard Ratio (HR) = 1.53, 95 % Confidence interval (CI) = 1.19–1.98). Sensitivity analyses demonstrated consistent patterns, with the sarcopenic obese group showing a 57 % elevated risk of KOA (HR = 1.57, 95%CI = 1.04–2.35) and the sarcopenic abdominal obesity group a 40 % increased risk (HR = 1.40, 95%CI = 1.08–1.80), both relative to the normal control cohort. Subgroup analyses revealed a significant interaction effect of gender on the results (P for interaction <0.05), with females in the sarcopenic overweight group showing a statistically significant difference compared to the normal group (HR = 1.45, 95 % CI = 1.06–1.99). Moreover, in the context of probable sarcopenic overweight and KOA, the probable sarcopenic overweight group (HR = 1.44, 95 % CI = 1.11–1.87) was associated with an increased risk of developing KOA.

Conclusion

This study is the first longitudinal investigation to examine the association between sarcopenic obesity (and probable sarcopenic obesity) and the risk of KOA in a large sample of middle-aged and elderly individuals. The findings suggest that through weight management and adequate muscle strength, it may be probable to reduce the risk of KOA in middle-aged and elderly populations, especially among women, thereby improving quality of life in later years.
中国中老年人群肌肉减少型肥胖与膝关节骨性关节炎风险之间的关系:一项为期7年的队列研究
目的:探讨中老年人肌肉减少型肥胖与膝骨性关节炎(KOA)发病的关系。方法:本研究利用中国健康与退休纵向研究(CHARLS)数据库的队列数据,以2011年无膝骨关节炎的中老年个体为研究对象。共有4299名年龄在45岁以上的符合纳入和排除标准的参与者被纳入。以超重作为肥胖的标准,参与者被分为四组:正常控制,仅超重,仅肌肉减少和肌肉减少超重。采用Cox比例风险模型进行生存分析,将正常对照组与其他三组进行比较,评估其对膝骨关节炎发生风险的影响。采用肥胖肌肉减少症和腹部肥胖肌肉减少症进行敏感性分析,以确保结果的稳健性。此外,还进行了亚组分析,以探讨不同人群对结果的影响。最后,我们调查了可能的肌肉减少型肥胖与KOA之间的关系。结果:与正常对照组相比,肌减少型肥胖组KOA风险比(HR) = 1.53, 95%可信区间(CI) = 1.19 ~ 1.98,显著增高。敏感性分析显示了一致的模式,与正常对照组相比,肌肉减少肥胖组KOA风险增加57% (HR=1.57, 95%CI=1.04-2.35),肌肉减少腹部肥胖组KOA风险增加40% (HR=1.40, 95%CI=1.08-1.80)。亚组分析显示性别对结果有显著的交互作用(P为交互作用)
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来源期刊
Clinical nutrition ESPEN
Clinical nutrition ESPEN NUTRITION & DIETETICS-
CiteScore
4.90
自引率
3.30%
发文量
512
期刊介绍: Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.
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