L Fang, H Cao, Y Guo, Y Zhang, M Ge, Y Min, W Yu, X Jiang
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引用次数: 0
Abstract
1. Artemisia capillaris Thunb. (ACT) is a semi-scrubby herb from the Artemisia genus of the Asteraceae family that has hepatobiliary effects. This study evaluated the effect of ACT on hepatic lipid buildup in laying hens and, hence, as a feed additive to treat fatty liver in laying hens.2. Hens were randomly allocated into one of five treatment groups: positive control group (to 35 weeks of age; PC), fatty liver control group (to 75 weeks of age; 75W), ACT low-dose intervention (1 g/h/d) group (to 75 weeks of age; 75W+L), ACT medium-dose intervention (2 g/h/d) group (to 75 weeks of age; 75W+M) and ACT high-dose intervention (4 g/h/d) group (to 75 weeks of age; 75W+H).3. Feeding ACT decreased the liver index and tissue sections revealed that it minimised hepatocellular steatosis and vacuolar degeneration, considerably lowered liver indicator enzyme (aspartate transaminase, AST and alanine transaminase, ALT) concentrations and improved liver function. Regarding hepatic fat formation, ACT reduced the amount of lipid droplets in the liver; the ACT group dramatically lowered serum triglycerides (TG), serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) while increasing high-density lipoprotein cholesterol (HDL-C). In terms of reproductive hormone markers, follicle-stimulating hormone (FSH) and luteinising hormone (LH) and vitellogenin (VTG) levels were dramatically elevated, while oestradiol (E2) levels were decreased in hens fed the ACT diets.4. Cyberpharmacology and molecular docking revealed that ACT primary target was AKT, which was able to reduce AKT protein phosphorylation as well as the protein expression of fatty acid synthesis-related genes ACC, FAS and SREBP-1c in the liver.5. In conclusion, ACT was able to dramatically reduce the protein expression of fatty acid production genes, enhance hepatic lipid metabolism in laying hens, reverse hepatic and dyslipidemic abnormalities in laying hens and ameliorate fatty liver conditions.
期刊介绍：
From its first volume in 1960, British Poultry Science has been a leading international journal for poultry scientists and advisers to the poultry industry throughout the world. Over 60% of the independently refereed papers published originate outside the UK. Most typically they report the results of biological studies with an experimental approach which either make an original contribution to fundamental science or are of obvious application to the industry. Subjects which are covered include: anatomy, embryology, biochemistry, biophysics, physiology, reproduction and genetics, behaviour, microbiology, endocrinology, nutrition, environmental science, food science, feeding stuffs and feeding, management and housing welfare, breeding, hatching, poultry meat and egg yields and quality.Papers that adopt a modelling approach or describe the scientific background to new equipment or apparatus directly relevant to the industry are also published. The journal also features rapid publication of Short Communications. Summaries of papers presented at the Spring Meeting of the UK Branch of the WPSA are published in British Poultry Abstracts .
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