Cytomegalovirus: An undervalued biological parameter of cognition in schizophrenia

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-06-04 DOI:10.1016/j.brainres.2025.149719

Zifan You, Liangliang Wang, Shanshan Chen, Luyao Zou, Jinsong Tang

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引用次数: 0

Abstract

There is growing evidence that the brain is not an immune-privileged area, with central nervous system (CNS) cells being susceptible to inflammation as the brain responds to infection. Among the myriad of pathogens capable of infiltrating the neural environment, cytomegalovirus (CMV) has been one of the most extensively studied. Notably, CMV has been implicated in a range of neuropsychiatric disorders, including schizophrenia (SCZ). The objective of this review is to provide a comprehensive analysis of the impact of CMV on cognitive function in SCZ. Our review covers studies that explore the intersection of SCZ and CMV infection, thus establishing a theoretical framework for understanding the cognitive deficits associated with CMV. Recent findings regarding the SCZ-CMV relationship include: (1) the association of CMV with cognitive impairment, (2) CMV-related neuropathology and neuroimaging findings linked to the pathogenesis of cognitive deficits, and (3) therapeutic interventions for CMV in vivo. Given that no prior studies have explored the causal relationship between CMV biomarkers and cognitive features in SCZ, we have employed Mendelian randomization (MR) analysis to further investigate these associations. Through this review, we aim to offer new insights into the pathogenesis, diagnosis, treatment, and prognosis of SCZ by exploring the relationship between CMV and SCZ.

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巨细胞病毒：精神分裂症认知的一个被低估的生物学参数。

越来越多的证据表明，大脑并不是一个免疫特权区域，在大脑对感染做出反应时，中枢神经系统（CNS）细胞很容易受到炎症的影响。在众多能够浸润神经环境的病原体中，巨细胞病毒（CMV）一直是研究最广泛的病原体之一。值得注意的是，巨细胞病毒与包括精神分裂症（SCZ）在内的一系列神经精神疾病有关。本综述的目的是全面分析巨细胞病毒对SCZ认知功能的影响。我们的综述涵盖了探索SCZ和巨细胞病毒感染交叉的研究，从而为理解巨细胞病毒相关的认知缺陷建立了一个理论框架。关于SCZ-CMV关系的最新发现包括：(1)CMV与认知障碍的关联，(2)CMV相关的神经病理学和神经影像学发现与认知障碍的发病机制有关，以及(3)CMV在体内的治疗干预。鉴于之前没有研究探索巨细胞病毒生物标志物与SCZ认知特征之间的因果关系，我们采用孟德尔随机化（MR）分析来进一步研究这些关联。本文旨在通过探讨巨细胞病毒与SCZ的关系，为SCZ的发病机制、诊断、治疗及预后提供新的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.