{"title":"Macroscale optimal size of ICM vesicles regulated by quantum design principle in LH2 structure.","authors":"Ying Zhang, Qianjin Chu, Luchao Du, Yugui Yao, Hailong Chen, Peng Wang, Jianping Zhang, Mingqing Chen, Lingfeng Peng, Yuxiang Weng","doi":"10.1016/j.bpj.2025.06.004","DOIUrl":null,"url":null,"abstract":"<p><p>The photosynthetic bacterial light-harvesting antenna complex 2 (LH2), consisting of ring-like bacteriochlorophylls aggregates, constitutes an optimal excitonic structure for efficient energy transfer. Any distortion from this structure would cause efficiency losses. When adapted to low-light growing conditions, LH2-embedded membranes form vesicles to enhance light capture, albeit at the expense of curvature-induced LH2 deformation. Therefore, evolution should optimize vesicle sizes for overall light utilization efficiency. To unveil this optimization strategy, LH2 was assembled onto silica nanoparticles of a wide size region to simulate LH2 deformation, which was characterized by the B850 lifetime both theoretically and experimentally. We found that LH2 was undeformed only within the size range of 50-80 nm, akin to vesicle sizes observed in bacteria, suggesting that vesicle size optimization follows the LH2 structural design principle.</p>","PeriodicalId":8922,"journal":{"name":"Biophysical journal","volume":" ","pages":"2317-2326"},"PeriodicalIF":3.2000,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysical journal","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.bpj.2025.06.004","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0
Abstract
The photosynthetic bacterial light-harvesting antenna complex 2 (LH2), consisting of ring-like bacteriochlorophylls aggregates, constitutes an optimal excitonic structure for efficient energy transfer. Any distortion from this structure would cause efficiency losses. When adapted to low-light growing conditions, LH2-embedded membranes form vesicles to enhance light capture, albeit at the expense of curvature-induced LH2 deformation. Therefore, evolution should optimize vesicle sizes for overall light utilization efficiency. To unveil this optimization strategy, LH2 was assembled onto silica nanoparticles of a wide size region to simulate LH2 deformation, which was characterized by the B850 lifetime both theoretically and experimentally. We found that LH2 was undeformed only within the size range of 50-80 nm, akin to vesicle sizes observed in bacteria, suggesting that vesicle size optimization follows the LH2 structural design principle.
期刊介绍：
BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding ofexperimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.
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