Droplet acoustofluidics: Recent progress and challenges.

IF 2.6 4区工程技术 Q2 BIOCHEMICAL RESEARCH METHODS

Biomicrofluidics Pub Date : 2025-06-04 eCollection Date: 2025-05-01 DOI:10.1063/5.0261531

Mushtaq Ali, Woohyuk Kim, Muhammad Soban Khan, Mehmet Akif Sahin, Ghulam Destgeer, Jinsoo Park

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引用次数: 0

Abstract

Acoustofluidics, offering contact-free and precise manipulation of micro-objects, has emerged as a transformative tool for various biological and medical applications. In recent years, significant advancements have been made in droplet manipulation using acoustic waves. This review provides an in-depth exploration of acoustofluidic techniques for droplet manipulation, presenting a balanced perspective on the role of this versatile platform across diverse applications. The paper begins by introducing the underlying mechanism of acoustic forces acting on the droplets, followed by a comprehensive discussion of acoustofluidic techniques tailored for essential unit operations, such as droplet generation, separation, merging, splitting, steering, trapping, in-droplet sample manipulation, sample control within sessile droplets, and digital acoustofluidics. Finally, the prospects and limitations of acoustofluidics for droplet manipulations are also discussed, suggesting the future direction of droplet acoustofluidics research.

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液滴声流体学：最新进展与挑战。

声流体技术提供了对微型物体的无接触和精确操作，已经成为各种生物和医学应用的变革性工具。近年来，在利用声波操纵液滴方面取得了重大进展。这篇综述对液滴操纵的声流技术进行了深入的探索，从平衡的角度介绍了这种多功能平台在不同应用中的作用。本文首先介绍了作用在液滴上的声学力的基本机制，然后全面讨论了为基本单元操作定制的声流体技术，如液滴产生、分离、合并、分裂、转向、捕获、液滴内样品操作、无底液滴内样品控制和数字声流体。最后，讨论了声流体学在液滴控制方面的应用前景和局限性，提出了液滴声流体学研究的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomicrofluidics 生物-纳米科技

CiteScore

5.80

自引率

3.10%

发文量

审稿时长

1.3 months

期刊介绍： Biomicrofluidics (BMF) is an online-only journal published by AIP Publishing to rapidly disseminate research in fundamental physicochemical mechanisms associated with microfluidic and nanofluidic phenomena. BMF also publishes research in unique microfluidic and nanofluidic techniques for diagnostic, medical, biological, pharmaceutical, environmental, and chemical applications. BMF offers quick publication, multimedia capability, and worldwide circulation among academic, national, and industrial laboratories. With a primary focus on high-quality original research articles, BMF also organizes special sections that help explain and define specific challenges unique to the interdisciplinary field of biomicrofluidics. Microfluidic and nanofluidic actuation (electrokinetics, acoustofluidics, optofluidics, capillary) Liquid Biopsy (microRNA profiling, circulating tumor cell isolation, exosome isolation, circulating tumor DNA quantification) Cell sorting, manipulation, and transfection (di/electrophoresis, magnetic beads, optical traps, electroporation) Molecular Separation and Concentration (isotachophoresis, concentration polarization, di/electrophoresis, magnetic beads, nanoparticles) Cell culture and analysis(single cell assays, stimuli response, stem cell transfection) Genomic and proteomic analysis (rapid gene sequencing, DNA/protein/carbohydrate arrays) Biosensors (immuno-assay, nucleic acid fluorescent assay, colorimetric assay, enzyme amplification, plasmonic and Raman nano-reporter, molecular beacon, FRET, aptamer, nanopore, optical fibers) Biophysical transport and characterization (DNA, single protein, ion channel and membrane dynamics, cell motility and communication mechanisms, electrophysiology, patch clamping). Etc...