Rising mortality in cerebral atherosclerosis-related deaths in the United States (1999-2020): a 21-year retrospective analysis of CDC-WONDER database.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Annals of Medicine and Surgery Pub Date : 2025-05-21 eCollection Date: 2025-06-01 DOI:10.1097/MS9.0000000000003292
Muhammad Hamza Shuja, Ali Salman, Afia Jawaid, Shafin Bin Ameen, Mishal Abid, Zoya Khemane, Maliha Edhi, Marc Fakhoury, Minal Hasan
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Abstract

Background: Cerebral Atherosclerosis-related mortality remains a major public health issue. This study analyzes trends in age-adjusted mortality rates (AAMR) for cerebral atherosclerosis deaths in the United States from 1999 to 2020.

Methods: Mortality data from 1999 to 2020 for adults aged 25 years and older were analyzed. AAMRs were calculated, and trends were examined for the overall population, as well as by gender, urban-rural areas, race/ethnicity, and census region. Annual percentage changes (APC) were calculated to assess mortality trends.

Results: A total of 146 016 deaths were recorded. The overall AAMR increased from 3.44 (95% CI: 3.36-3.53) in 1999 to 7.43 (95% CI: 7.32-7.53) in 2020. Mortality rates initially decreased from 1999 to 2006 (APC: -11.4 [95% CI: -19.7 to -7.85]), followed by a rise, with the sharpest increase from 2013 to 2016 (APC: 36.7 [95% CI: 23.0 to 45.9]). Mortality trends were similar across genders, with both males and females showing increases after an initial decline. Higher AAMRs were seen in urban areas compared to rural regions, with urban areas experiencing a steeper rise post-2013. Racial/ethnic disparities were apparent, with Hispanics showing the largest increase in mortality rates from 1999 to 2020. Regional disparities indicated the highest mortality rates in the South, with a sharp rise from 2012 to 2015.

Conclusion: Cerebral Atherosclerosis-related mortality rates have significantly increased from 1999 to 2020, with notable disparities across gender, race, and geographic regions. Targeted interventions are needed to address these disparities and reduce mortality, particularly in high-risk populations.

美国脑动脉粥样硬化相关死亡死亡率上升(1999-2020):对CDC-WONDER数据库的21年回顾性分析
背景:脑动脉粥样硬化相关的死亡率仍然是一个主要的公共卫生问题。本研究分析了1999年至2020年美国脑动脉粥样硬化死亡的年龄调整死亡率(AAMR)趋势。方法:对1999 ~ 2020年25岁及以上成人的死亡率资料进行分析。计算了aamr,并检查了总体人口以及性别、城乡地区、种族/民族和人口普查地区的趋势。计算年百分比变化(APC)以评估死亡率趋势。结果:共记录死亡146 016例。总体AAMR从1999年的3.44 (95% CI: 3.36-3.53)增加到2020年的7.43 (95% CI: 7.32-7.53)。死亡率从1999年到2006年开始下降(APC: -11.4 [95% CI: -19.7至-7.85]),随后上升,2013年至2016年增幅最大(APC: 36.7 [95% CI: 23.0至45.9])。死亡率的趋势在性别之间是相似的,男性和女性在最初的下降之后都出现了上升。与农村地区相比,城市地区的aamr更高,2013年后城市地区的上升幅度更大。种族/族裔差异很明显,1999年至2020年,西班牙裔死亡率增幅最大。区域差异表明,南方的死亡率最高,从2012年到2015年急剧上升。结论:1999年至2020年,脑动脉粥样硬化相关死亡率显著上升,性别、种族和地理区域差异显著。需要采取有针对性的干预措施来解决这些差异并降低死亡率,特别是在高危人群中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Medicine and Surgery
Annals of Medicine and Surgery MEDICINE, GENERAL & INTERNAL-
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