Outcomes and prognostic factors of tonsillar Kaposi sarcoma in the United States SEER Database.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Annals of Medicine and Surgery Pub Date : 2025-04-22 eCollection Date: 2025-06-01 DOI:10.1097/MS9.0000000000003294
Akef Obeidat, Tarek Ziad Arabi, Abdul-Rahman Elhassan, Safia Elhassan, Marwan Alaswad, Belal Nedal Sabbah
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引用次数: 0

Abstract

Tonsillar Kaposi sarcoma (KS) is an extremely rare manifestation of KS, a neoplasm associated with human herpesvirus-8 and often linked to immunocompromised individuals. This study aims to analyze the outcomes and prognostic factors of tonsillar KS using data from the SEER (Surveillance, Epidemiology, and End Results) database, covering cases from 2000 to 2020. A total of 42 patients were identified, with the vast majority being male (97.6%) and a mean age of 40.1 years. Tumors were primarily localized (42.9%), and treatment modalities varied, with radiation therapy being the most common (38.1%), followed by chemotherapy (21.4%) and surgery (19.0%). Survival analysis showed that 21.4% of patients had died by the last follow-up, but the median survival time was not reached, indicating a relatively favorable prognosis. No statistically significant survival differences were observed based on treatment modality or other demographic factors, though there were trends towards worse outcomes for patients with regional disease and longer delays in treatment initiation. The study highlights the rarity of tonsillar KS, its demographic profile, and suggests a generally positive prognosis, although further research is needed to optimize treatment strategies for this rare form of KS.

美国SEER数据库中扁桃体卡波西肉瘤的预后和预后因素。
扁桃体卡波西肉瘤(KS)是一种极其罕见的KS表现,是一种与人类疱疹病毒-8相关的肿瘤,通常与免疫功能低下的个体有关。本研究旨在利用SEER(监测、流行病学和最终结果)数据库的数据分析扁桃体KS的结局和预后因素,涵盖2000年至2020年的病例。共发现42例患者,绝大多数为男性(97.6%),平均年龄40.1岁。肿瘤主要局限于局部(42.9%),治疗方式多种多样,最常见的是放疗(38.1%),其次是化疗(21.4%)和手术(19.0%)。生存分析显示,21.4%的患者在最后一次随访时死亡,但中位生存时间未达到,预后较好。在治疗方式或其他人口统计学因素的基础上,没有观察到统计学上显著的生存差异,尽管区域性疾病患者的预后更差,开始治疗的延迟时间更长。该研究强调了扁桃体KS的罕见性,其人口统计学特征,并表明总体预后良好,尽管需要进一步研究来优化这种罕见形式的KS的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annals of Medicine and Surgery
Annals of Medicine and Surgery MEDICINE, GENERAL & INTERNAL-
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5.90%
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