Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechanisms of Action, Aesthetic Effectiveness, Satisfaction, and Safety Profile.
{"title":"Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechanisms of Action, Aesthetic Effectiveness, Satisfaction, and Safety Profile.","authors":"Renald Meçani, Mojgan Amiri, Jonathan Kadouch, Dusan Sajic, Frank Lin, Jessie Cheung, Diana Barrera, Omar Haroon, Susana Sil-Zavaleta, Yates Chao, Taulant Muka","doi":"10.1007/s00266-025-04904-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The use of dermal fillers has become increasingly popular in aesthetic medicine for facial rejuvenation and skin enhancement. Hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) are particularly well-known for their unique benefits. This systematic review evaluates the combinations (e.g., using two separate treatments together) and hybrid treatments of HA and CaHA (e.g., direct syringe-to-syringe mixing), focusing on their mechanisms of action, aesthetic effectiveness, patient satisfaction, and safety.</p><p><strong>Methods: </strong>Six bibliographic databases were searched for human and non-human studies that explored the mechanistic effects of combined and hybrid HA and CaHA treatments, and their aesthetic effectiveness, skin quality, satisfaction, and safety were included. Due to high heterogeneity among included studies, a qualitative synthesis of the evidence was performed.</p><p><strong>Results: </strong>The combination of HA and CaHA stimulates collagen synthesis through different molecular pathways. The combined and hybrid treatments are associated with high aesthetic effectiveness in various facial areas, as reported by both investigators and subjects. Additionally, the combinations and hybrid treatments show high satisfaction rates and have a safe profile, with minor, self-resolving adverse effects. A trend of slight decline in both aesthetic improvement and treatment satisfaction was observed after six months.</p><p><strong>Conclusions: </strong>The combinations and hybrid treatments of HA and CaHA appear to be a promising, safe, and efficacious treatment for facial rejuvenation, offering both immediate volumizing effects and longer-term benefits through collagen synthesis. Future research should employ rigorous study designs aimed at refining treatment protocols and generating strong, long-term evidence for the safety and effectiveness of this combination or hybrid therapy in aesthetic medicine.</p><p><strong>Level of evidence ii: </strong>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .</p>","PeriodicalId":7609,"journal":{"name":"Aesthetic Plastic Surgery","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aesthetic Plastic Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00266-025-04904-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The use of dermal fillers has become increasingly popular in aesthetic medicine for facial rejuvenation and skin enhancement. Hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) are particularly well-known for their unique benefits. This systematic review evaluates the combinations (e.g., using two separate treatments together) and hybrid treatments of HA and CaHA (e.g., direct syringe-to-syringe mixing), focusing on their mechanisms of action, aesthetic effectiveness, patient satisfaction, and safety.
Methods: Six bibliographic databases were searched for human and non-human studies that explored the mechanistic effects of combined and hybrid HA and CaHA treatments, and their aesthetic effectiveness, skin quality, satisfaction, and safety were included. Due to high heterogeneity among included studies, a qualitative synthesis of the evidence was performed.
Results: The combination of HA and CaHA stimulates collagen synthesis through different molecular pathways. The combined and hybrid treatments are associated with high aesthetic effectiveness in various facial areas, as reported by both investigators and subjects. Additionally, the combinations and hybrid treatments show high satisfaction rates and have a safe profile, with minor, self-resolving adverse effects. A trend of slight decline in both aesthetic improvement and treatment satisfaction was observed after six months.
Conclusions: The combinations and hybrid treatments of HA and CaHA appear to be a promising, safe, and efficacious treatment for facial rejuvenation, offering both immediate volumizing effects and longer-term benefits through collagen synthesis. Future research should employ rigorous study designs aimed at refining treatment protocols and generating strong, long-term evidence for the safety and effectiveness of this combination or hybrid therapy in aesthetic medicine.
Level of evidence ii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
期刊介绍：
Aesthetic Plastic Surgery is a publication of the International Society of Aesthetic Plastic Surgery and the official journal of the European Association of Societies of Aesthetic Plastic Surgery (EASAPS), Società Italiana di Chirurgia Plastica Ricostruttiva ed Estetica (SICPRE), Vereinigung der Deutschen Aesthetisch Plastischen Chirurgen (VDAPC), the Romanian Aesthetic Surgery Society (RASS), Asociación Española de Cirugía Estética Plástica (AECEP), La Sociedad Argentina de Cirugía Plástica, Estética y Reparadora (SACPER), the Rhinoplasty Society of Europe (RSE), the Iranian Society of Plastic and Aesthetic Surgeons (ISPAS), the Singapore Association of Plastic Surgeons (SAPS), the Australasian Society of Aesthetic Plastic Surgeons (ASAPS), the Egyptian Society of Plastic and Reconstructive Surgeons (ESPRS), and the Sociedad Chilena de Cirugía Plástica, Reconstructiva y Estética (SCCP).
Aesthetic Plastic Surgery provides a forum for original articles advancing the art of aesthetic plastic surgery. Many describe surgical craftsmanship; others deal with complications in surgical procedures and methods by which to treat or avoid them. Coverage includes "second thoughts" on established techniques, which might be abandoned, modified, or improved. Also included are case histories; improvements in surgical instruments, pharmaceuticals, and operating room equipment; and discussions of problems such as the role of psychosocial factors in the doctor-patient and the patient-public interrelationships.
Aesthetic Plastic Surgery is covered in Current Contents/Clinical Medicine, SciSearch, Research Alert, Index Medicus-Medline, and Excerpta Medica/Embase.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
