Zhe Lei, Ning Su, Menglong Li, Yanan Sun, Zhenrui Pan, Kangdong Liu, Yueteng Zhang
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引用次数: 0
Abstract
Deuterium, an element recognized for its close association with cancer, is involved in every stage from tumorigenesis and basic research methodologies to clinical diagnosis, therapeutic interventions, and drug development. Several significant findings have emerged in this field. This review explores the potential mechanisms by which deuterons influence cancer initiation and progression in the form of deuterium oxide including deuterium-enriched water (DEW) and deuterium-depleted water (DDW). Besides, deuterium, a stable hydrogen isotope with unique physicochemical properties, also plays a pivotal role in detection and drug discovery. We delve into the importance of deuterium-labeled compound detection techniques-such as hydrogen-deuterium exchange mass spectrometry, deuterium metabolism imaging, Raman deuterium isotope probe techniques, and the applications of AI in Deuterium-related detection techniques-in identifying tumor biomarkers, elucidating metabolic pathways, and validating drug targets. The advantages and limitations of these techniques, particularly in the realm of imaging, are discussed. Deuterium-substituted drugs, such as donafenib, offer notable pharmacokinetic superiorities, including a significantly longer half-life and reduced toxicity compared to conventional chemotherapeutic agents. These characteristics make them promising candidates for cancer chemotherapy. In summary, this review examines the role of deuterium-related molecules in cancer development, detection, and treatment, including DEW, DDW, deuterium-substituted drugs, and deuterium-labeled compounds. Additionally, it highlights the latest advancements in deuterium-labeled compound detection technologies.
期刊介绍：
Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including:
combinatorial chemistry and parallel synthesis;
small molecule libraries;
microwave synthesis;
flow synthesis;
fluorous synthesis;
diversity oriented synthesis (DOS);
nanoreactors;
click chemistry;
multiplex technologies;
fragment- and ligand-based design;
structure/function/SAR;
computational chemistry and molecular design;
chemoinformatics;
screening techniques and screening interfaces;
analytical and purification methods;
robotics, automation and miniaturization;
targeted libraries;
display libraries;
peptides and peptoids;
proteins;
oligonucleotides;
carbohydrates;
natural diversity;
new methods of library formulation and deconvolution;
directed evolution, origin of life and recombination;
search techniques, landscapes, random chemistry and more;
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