{"title":"Enhanced Carboxymethyl Cellulose-Based Hydrogels for Wound Dressings.","authors":"Nannan Zhong, Ning Cao, Ziyang Cheng, Shangshang Fang, Minghan Jiang, Jingyi Guan, Wenbo Wang, Xiaobei Zang","doi":"10.1021/acsabm.5c00815","DOIUrl":null,"url":null,"abstract":"<p><p>The development of ideal wound dressings with superior properties represents a critical demand in wound management. In recent years, carboxymethyl cellulose (CMC) has garnered significant attention as a high-value material for biomedical applications. Due to its exceptional biocompatibility, low toxicity, and functional versatility, carboxymethyl cellulose has emerged as a promising candidate for developing hydrogel-based wound dressings. This review systematically examines the potential of carboxymethyl cellulose and carboxymethyl cellulose-derived hydrogel dressings as advanced wound care solutions, emphasizing advancements in performance metrics and multifunctional applications, including self-healing capabilities, pH responsiveness, and sustained drug release. Furthermore, we comprehensively summarize recent progress in carboxymethyl cellulose-based hydrogel biomaterials for wound dressing applications and propose strategic prospects for future development to enhance the clinical translation of CMC hydrogel systems.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00815","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
The development of ideal wound dressings with superior properties represents a critical demand in wound management. In recent years, carboxymethyl cellulose (CMC) has garnered significant attention as a high-value material for biomedical applications. Due to its exceptional biocompatibility, low toxicity, and functional versatility, carboxymethyl cellulose has emerged as a promising candidate for developing hydrogel-based wound dressings. This review systematically examines the potential of carboxymethyl cellulose and carboxymethyl cellulose-derived hydrogel dressings as advanced wound care solutions, emphasizing advancements in performance metrics and multifunctional applications, including self-healing capabilities, pH responsiveness, and sustained drug release. Furthermore, we comprehensively summarize recent progress in carboxymethyl cellulose-based hydrogel biomaterials for wound dressing applications and propose strategic prospects for future development to enhance the clinical translation of CMC hydrogel systems.
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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