Postpartum QT Prolongation in a Long QT Syndrome Type 1 Patient

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Noninvasive Electrocardiology Pub Date : 2025-06-10 DOI:10.1111/anec.70079

Lilli C. Wiedenmann, Joachim R. Ehrlich, Ilan Goldenberg

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引用次数: 0

Abstract

Background

Female LQTS patients are at high risk for arrhythmogenic events during the postpartum period due to hormonal influence on cardiac repolarization.

Methods

We observed an LQT1 patient with previous cardiac events during pregnancy and 3 weeks postpartum. We obtained ECG recordings and quantified sex hormone levels.

Results

Peak pregnancy: QTc: 420 ± 7 ms, Estradiol: 24.18 ng/mL, Progesterone: 218 ng/mL. Seven days postpartum: QTc prolongation to 455 ± 5 ms. 22 days postpartum: QTc: 452 ± 5, Estradiol: 0.013 ng/mL, Progesterone: 0.25 ng/mL.

Conclusions

Estradiol and Progesterone decline rapidly after birth, correlating to QTc prolongation and elevated risk for arrhythmogenic events. Therefore, modification of pharmacological or device therapy may be considered.

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1型长QT综合征患者的产后QT间期延长

背景由于激素对心脏复极的影响，女性LQTS患者在产后发生致心律失常事件的风险较高。方法观察1例LQT1患者妊娠期及产后3周有心脏事件。我们获得了心电图记录并量化了性激素水平。结果妊娠高峰：QTc: 420±7 ms，雌二醇：24.18 ng/mL，孕酮：218 ng/mL。产后7天：QTc延长至455±5 ms。产后22天：QTc: 452±5，雌二醇：0.013 ng/mL，黄体酮：0.25 ng/mL。结论出生后雌二醇和黄体酮迅速下降，与QTc延长和心律失常事件发生风险升高有关。因此，可以考虑修改药理学或器械治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Noninvasive Electrocardiology 医学-心血管系统

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.