Remnant cholesterol and post-stroke cognitive function: A multicenter prospective study

IF 1.9 4区 医学 Q3 CLINICAL NEUROLOGY
Hong Li , Zhengbao Zhu , Mengyao Shi , Hao Peng , Daoxia Guo , Tan Xu , Jing Chen , Yonghong Zhang , Jiang He , Chongke Zhong , Xiaoqing Bu
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引用次数: 0

Abstract

Objective

To explore the association between baseline remnant cholesterol (RC) levels and post-stroke cognitive impairment (PSCI) at three months following the event.

Methods

The data utilized in this research originated from a pre-arranged subsidiary investigation of the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). RC levels were determined using the formula: RC (mmol/L) = total cholesterol (TC) − low-density lipoprotein cholesterol (LDL-C) − high-density lipoprotein cholesterol (HDL-C), and cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at three months post-stroke. The relationship between RC tertiles and PSCI was examined using binary logistic regression analysis.

Results

In this prospective study, 523 participants were included. Patients with the highest tertile of RC levels exhibited a significantly decreased risk of developing PSCI in comparison to those in the lowest tertile [Odds Ratio (OR): 0.38; 95% Confidence Interval (CI): 0.23–0.63; P for trend < 0.001]. This relationship remained even after adjusting for multiple variables (OR: 0.40; 95% CI: 0.21–0.75; P for trend < 0.001). Among patients with body mass index (BMI) ≤ 24.9 kg/m2, those in the second and highest tertiles of RC levels showed reduced risks of PSCI (OR: 0.32; 95% CI: 0.13–0.80 and OR: 0.16; 95% CI: 0.06–0.44, respectively), compared to the lowest tertile; however, this relationship was not observed in patients with BMI > 24.9 kg/m2 (P for interaction = 0.036).

Conclusions

In ischemic stroke patients, elevated baseline RC levels were linked to a decreased risk of PSCI at 3 months, particularly among those who were not overweight.
残余胆固醇与脑卒中后认知功能:一项多中心前瞻性研究
目的探讨基线残余胆固醇(RC)水平与脑卒中后3个月认知功能障碍(PSCI)的关系。方法本研究使用的数据来源于中国急性缺血性卒中降压试验(CATIS)预先安排的辅助调查。RC水平的测定采用以下公式:RC (mmol/L) =总胆固醇(TC) -低密度脂蛋白胆固醇(LDL-C) -高密度脂蛋白胆固醇(HDL-C),脑卒中后3个月通过迷你精神状态检查(MMSE)和蒙特利尔认知评估(MoCA)评估认知功能。采用二元logistic回归分析检验了RC砖与PSCI之间的关系。结果本前瞻性研究纳入523例受试者。与最低分位数的患者相比,RC水平最高的患者发生PSCI的风险显著降低[优势比(OR): 0.38;95%置信区间(CI): 0.23-0.63;P代表趋势<;0.001]。即使在调整多个变量后,这种关系仍然存在(OR: 0.40;95% ci: 0.21-0.75;P代表趋势<;0.001)。在体重指数(BMI)≤24.9 kg/m2的患者中,RC水平在第二和最高三分位数的患者发生PSCI的风险较低(OR: 0.32;95% CI: 0.13-0.80, OR: 0.16;95% CI分别为0.06-0.44),与最低分位数相比;然而,这种关系在BMI >;24.9 kg/m2(相互作用P = 0.036)。结论:在缺血性卒中患者中,基线RC水平升高与3个月时PSCI风险降低有关,特别是那些不超重的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Clinical Neuroscience
Journal of Clinical Neuroscience 医学-临床神经学
CiteScore
4.50
自引率
0.00%
发文量
402
审稿时长
40 days
期刊介绍: This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology. The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.
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