Hong Li , Zhengbao Zhu , Mengyao Shi , Hao Peng , Daoxia Guo , Tan Xu , Jing Chen , Yonghong Zhang , Jiang He , Chongke Zhong , Xiaoqing Bu
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引用次数: 0
Abstract
Objective
To explore the association between baseline remnant cholesterol (RC) levels and post-stroke cognitive impairment (PSCI) at three months following the event.
Methods
The data utilized in this research originated from a pre-arranged subsidiary investigation of the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS). RC levels were determined using the formula: RC (mmol/L) = total cholesterol (TC) − low-density lipoprotein cholesterol (LDL-C) − high-density lipoprotein cholesterol (HDL-C), and cognitive function was assessed by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) at three months post-stroke. The relationship between RC tertiles and PSCI was examined using binary logistic regression analysis.
Results
In this prospective study, 523 participants were included. Patients with the highest tertile of RC levels exhibited a significantly decreased risk of developing PSCI in comparison to those in the lowest tertile [Odds Ratio (OR): 0.38; 95% Confidence Interval (CI): 0.23–0.63; P for trend < 0.001]. This relationship remained even after adjusting for multiple variables (OR: 0.40; 95% CI: 0.21–0.75; P for trend < 0.001). Among patients with body mass index (BMI) ≤ 24.9 kg/m2, those in the second and highest tertiles of RC levels showed reduced risks of PSCI (OR: 0.32; 95% CI: 0.13–0.80 and OR: 0.16; 95% CI: 0.06–0.44, respectively), compared to the lowest tertile; however, this relationship was not observed in patients with BMI > 24.9 kg/m2 (P for interaction = 0.036).
Conclusions
In ischemic stroke patients, elevated baseline RC levels were linked to a decreased risk of PSCI at 3 months, particularly among those who were not overweight.
期刊介绍:
This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology.
The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.