Effects of exercise intervention on exercise capacity and cardiopulmonary function in patients with atrial fibrillation: A randomized controlled trial systematic review and meta-analysis

Medicina clinica (English ed.) Pub Date : 2025-06-09 DOI:10.1016/j.medcle.2025.106908

Zhang Shuai , Mao Su Jie , Xiao Kai Wen , Hong Xu , Lu Yuan

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Abstract

Background

Atrial fibrillation (AF) is a common cardiac arrhythmia that significantly impacts the cardiopulmonary function and quality of life of patients. Despite various treatment strategies, non-pharmacological interventions, particularly exercise interventions, have gained attention in recent years.

Objective

Through systematic review and meta-analysis, this study explores the impact of physical activity on the exercise capacity and quality of life of AF patients. It assesses the safety, clinical outcomes, and physiological mechanisms of exercise intervention in the treatment of AF.

Methods

The systematic review and individual patient data (IPD) meta-analysis method were employed, following the PRISMA-IPD guidelines, for literature selection, data extraction, and quality assessment. The analysis focused on the impact of exercise on the cardiopulmonary function and quality of life of AF patients in randomized controlled trials.

Results

A total of 12 randomized controlled trials involving 287 AF patients were included. Meta-analysis demonstrated a significant improvement in the 6-minute walk test capacity (SMD = 87.87, 95% CI [42.23, 133.51]), static heart rate improvement (SMD = −7.63, 95% CI [−11.42, −3.85]), and cardiopulmonary function enhancement (SMD = 2.37, 95% CI [0.96, 3.77]) due to exercise. There was also a significant improvement in the quality of life (SMD = 0.720, 95% CI [0.038, 1.402]).

Conclusion

Exercise has a significant effect on improving exercise capacity and cardiopulmonary function in patients with atrial fibrillation. Particularly, high-intensity exercise training has a more significant impact on improving cardiopulmonary function and exercise capacity, emphasizing the importance of personalized exercise plans in enhancing the cardiopulmonary health of AF patients. Further research is needed to explore the effects of exercise on improving the quality of life in the future.

PROSPERO ID: CRD2023493917.

查看原文本刊更多论文

运动干预对房颤患者运动能力和心肺功能的影响：一项随机对照试验、系统评价和荟萃分析

心房纤颤（AF）是一种常见的心律失常，严重影响患者的心肺功能和生活质量。尽管有各种各样的治疗策略，非药物干预，特别是运动干预，近年来已经引起了人们的关注。目的通过系统回顾和荟萃分析，探讨体育锻炼对房颤患者运动能力和生活质量的影响。评估运动干预治疗af的安全性、临床结果和生理机制。方法采用系统综述和个体患者数据（IPD）荟萃分析方法，遵循PRISMA-IPD指南，进行文献选择、数据提取和质量评估。在随机对照试验中，分析运动对房颤患者心肺功能和生活质量的影响。结果共纳入12项随机对照试验，共287例房颤患者。meta分析显示，运动对6分钟步行测试能力（SMD = 87.87, 95% CI[42.23, 133.51]）、静态心率改善（SMD = - 7.63, 95% CI[- 11.42, - 3.85]）和心肺功能增强（SMD = 2.37, 95% CI[0.96, 3.77]）有显著改善。生活质量也有显著改善（SMD = 0.720, 95% CI[0.038, 1.402]）。结论运动对提高房颤患者的运动能力和心肺功能有显著作用。特别是高强度运动训练对提高心肺功能和运动能力的影响更为显著，强调了个性化运动计划对增强房颤患者心肺健康的重要性。未来需要进一步的研究来探索运动对改善生活质量的影响。普洛斯彼罗id: crd2023493917。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medicina clinica (English ed.)

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