Non-exercise estimation of Cardiorespiratory fitness as a mediator in the relationship between physical comorbidity and depression among Korean cancer Survivors: Evidence from KNHANES 2016–2020

IF 2.3 3区医学 Q2 PSYCHIATRY

Mental Health and Physical Activity Pub Date : 2025-05-27 DOI:10.1016/j.mhpa.2025.100697

Youngyun Jin , Jinkyung Cho , Taewan Kim , Donghyun Kim

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引用次数: 0

Abstract

Objectives

This study aims to explore the relationship between physical comorbidity (PC) and depression among Korean adult cancer survivors, investigating the potential mediating role of non-exercise estimation of cardiorespiratory fitness (eCRF).

Methods

Data from 448 cancer survivors aged 20–64 years participating in the Korean National Health and Nutrition Examination Survey Ⅶ–Ⅷ (2016–2020) were analyzed. Depression was assessed using the 9-item Patient Health Questionnaire (PHQ-9). Subjects were categorized into two groups: normal and depression. PC was defined as a participant diagnosis by a physician or treatment at the time of the survey. eCRF was determined using sex and age-specific algorithms.

Results

A higher number of PC and lower eCRF were associated with an increased risk of depressive symptoms in cancer survivors. Additionally, the mediation analysis showed that eCRF mediated the relationship between PC and PHQ-9 scores (indirect effect = 0.013, bootstrap 95 %CI = 0.006 to 0.021), even after adjusting for covariates. The total effects of PC on the PHQ-9 score was 8.4 %, explaining the relationship.

Conclusion

These findings highlight the importance of regular physical activity to enhance cardiorespiratory fitness, a critical component of holistic survivorship care. Early physical activity interventions should be integrated into clinical practice to prevent depression in cancer survivors with chronic diseases.

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非运动估计的心肺健康是韩国癌症幸存者身体合并症和抑郁之间关系的中介：来自KNHANES 2016-2020的证据

目的探讨韩国成年癌症幸存者身体共病（PC）与抑郁的关系，探讨非运动心肺适能（eCRF）评估的潜在中介作用。方法对参加韩国国家健康与营养调查Ⅶ-Ⅷ（2016-2020）的448名20-64岁癌症幸存者的数据进行分析。采用9项患者健康问卷（PHQ-9）对抑郁症进行评估。受试者被分为两组：正常组和抑郁组。PC被定义为在调查时由医生诊断或治疗的参与者。eCRF采用性别和年龄特异性算法确定。结果较高的PC数量和较低的eCRF与癌症幸存者抑郁症状的风险增加相关。此外，中介分析显示，即使在调整协变量后，eCRF也介导了PC和PHQ-9分数之间的关系（间接效应= 0.013,bootstrap 95% CI = 0.006至0.021）。PC对PHQ-9得分的总影响为8.4%，解释了这种关系。结论：这些发现强调了规律的身体活动对增强心肺健康的重要性，这是整体生存护理的关键组成部分。早期身体活动干预应纳入临床实践，以预防患有慢性疾病的癌症幸存者的抑郁症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mental Health and Physical Activity PSYCHIATRY-

CiteScore

6.70

自引率

6.40%

发文量

审稿时长

32 days

期刊介绍： The aims of Mental Health and Physical Activity will be: (1) to foster the inter-disciplinary development and understanding of the mental health and physical activity field; (2) to develop research designs and methods to advance our understanding; (3) to promote the publication of high quality research on the effects of physical activity (interventions and a single session) on a wide range of dimensions of mental health and psychological well-being (eg, depression, anxiety and stress responses, mood, cognitive functioning and neurological disorders, such as dementia, self-esteem and related constructs, psychological aspects of quality of life among people with physical and mental illness, sleep, addictive disorders, eating disorders), from both efficacy and effectiveness trials;