New alkaloids isolated from the fruits of Capparis spinosa L. and their xanthine oxidase inhibitory activity

IF 1.4 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2025-06-09 DOI:10.1016/j.phytol.2025.103002

Mingyu Ba , Songfan Jiang , Zhen He , Wansheng Chen , Doudou Huang , Lianna Sun

引用次数: 0

Abstract

Two new alkaloids, 6-hydroxy-2′-(methylthio)-4′H-spiro[indoline-3,5′-thiazol]-2-one. (1), 2-(hydroxythio)-6-methoxy-1-methyl-1H-indole-3-carbaldehyde (2), as well as five known heteroauxin (3), 1,4-Dihydro-4-oxo-3-quinolinecarbonitrile (4), 3,4-dihydroxyquinoline-4-O-β-D-glucopyranoside (5), (2R,3R)-4-[5-(2-Furanyl)-2-pyrazinyl]-1,2,3-butanetriol (6) and 2-Methyl-7-benzoxazolecarboxylic acid (7) were isolated from the fruit of Capparis spinosa L. Their structures were elucidated mainly by NMR and HR-ESI-MS analysis, as well as on comparison with the data of known analogues. Compounds 1 and 2 exhibited xanthine oxidase (XOD) inhibitory activities, with values of 21.9 % and 19.8 % at 40 μM, respectively.

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从红椒果实中分离的新生物碱及其黄嘌呤氧化酶抑制活性

两个新的生物碱，6-羟基-2 ' -（甲基硫）-4 ' -h -螺[吲哚-3,5 ' -噻唑]-2- 1。((1), 2) - hydroxythio 6-methoxy-1-methyl-1h-indole-3-carbaldehyde(2),以及五个已知的吲哚乙酸(3),1,4-Dihydro-4-oxo-3-quinolinecarbonitrile (4), 3, 4-dihydroxyquinoline-4-O -β-D-glucopyranoside (5), (2 r, 3 r) 4 - 5 - (2-Furanyl) 2-pyrazinyl] [1, 2, 3-butanetriol(6)和2-Methyl-7-benzoxazolecarboxylic酸(7)被孤立的水果提物l .他们的结构是阐明主要由核磁共振和HR-ESI-MS分析,以及对比数据已知的类似物。在40 μM下，化合物1和2的黄嘌呤氧化酶（XOD）抑制率分别为21.9 %和19.8 %。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.