Application of heterologous extracellular vesicles and their analogs in anti-tumor activity research

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-06-06 DOI:10.1016/j.colsurfb.2025.114850

Jianguo Gao, Yanqing Wu, Yuwei Zhao, Yingzhi Lu, Xiaoqing Cai

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Abstract

Extracellular vesicles and their analogues can mediate intercellular communication for gene regulation, thereby activating corresponding cellular functions, which demonstrates promising applications in disease diagnosis and treatment. Extensive studies have indicated that extracellular vesicles and their analogues exhibit remarkable efficacy in various pharmacological activities, including anti-tumor effects, immune modulation, prevention and treatment of cardiovascular diseases, as well as tissue regeneration. Heterologous extracellular vesicles and their analogues possess diverse biological activities attributed to their compositions, distributions, and mechanisms of action. Their specific targeting ability, high biocompatibility, and low immunogenicity render them ideal delivery vehicles for precision therapeutic interventions. This article aims to comprehensively review the mechanisms of action of extracellular vesicles and their analogues in anti-tumor activity, as well as their unique advantages as drug delivery carriers, with the goal of providing a necessary reference foundation for further application and development in anti-tumor therapy.

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异源细胞外囊泡及其类似物在抗肿瘤活性研究中的应用

细胞外囊泡及其类似物可以介导细胞间的基因调控，从而激活相应的细胞功能，在疾病诊断和治疗中具有广阔的应用前景。大量研究表明，细胞外囊泡及其类似物在抗肿瘤、免疫调节、预防和治疗心血管疾病以及组织再生等方面具有显著的药理作用。异源细胞外囊泡及其类似物因其组成、分布和作用机制而具有多种生物活性。它们的特异性靶向能力、高生物相容性和低免疫原性使它们成为精确治疗干预的理想运载工具。本文就细胞外囊泡及其类似物的抗肿瘤作用机制及其作为药物传递载体的独特优势进行综述，以期为其在抗肿瘤治疗中的进一步应用和开发提供必要的参考基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.