Prevalence of multiple sclerosis in Spain. Estimates from the Primary Care Clinical Database (BDCAP)

IF 2.9 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2025-06-01 DOI:10.1016/j.nrl.2023.06.006

L. Cayuela , C. García-Muñoz , S. Sainz de la Maza , A. Cayuela

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引用次数: 0

Abstract

Introduction

The global prevalence of multiple sclerosis (MS) has increased in recent decades. However, there is a need for updated prevalence data for Spain.

Objective

To analyze the prevalence of MS in Spain using data from the Primary Care Clinical Database (BDCAP, for its Spanish initials) and to compare the prevalence results in different autonomous communities (AC) according to sex in 2021.

Methods

This cross-sectional study extracted data from the BDCAP on patients with MS according to sex, age, and place of residence in 2021. Crude prevalence rates were calculated, using the population assigned for each year of the study as the denominator. The geographic pattern of MS prevalence was analyzed using the following risk estimators: standardized prevalence ratio, smoothed relative risk (RR), and posterior probability of RR >1.

Results

We estimated 61 753 cases of MS, with a crude estimated prevalence rate of 132.0 cases per 100 000 person-years and a female/male ratio of 2.0. The age-standardized prevalence rate was 123.5 cases per 100 000 person-years. Age-specific prevalence rates were lower in men than in women. All indicators showed a north-south gradient. Seven ACs for women and 5 ACs for men showed a significant excess risk (primarily in the north of Spain), whereas 8 ACs for both women and men presented lower risk (mainly in the south).

Conclusions

Our results provide the most recent prevalence data for MS and the geographic patterns at the ACs level in Spain, revealing a north-south gradient. Our results pave the way for future strategies to manage the impact of MS in Spain and to understand causal hypotheses.

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西班牙多发性硬化症患病率。来自初级保健临床数据库（BDCAP）的估计

近几十年来，多发性硬化症（MS）的全球患病率有所上升。然而，需要更新西班牙的流行率数据。目的利用西班牙初级保健临床数据库（Primary Care Clinical Database， BDCAP）的数据分析西班牙MS的患病率，并比较2021年不同性别自治区（AC） MS的患病率结果。方法：本横断面研究根据性别、年龄和居住地提取2021年MS患者BDCAP数据。计算粗患病率，使用分配给研究的每一年的人口作为分母。使用以下风险估计值分析MS患病率的地理分布：标准化患病率、平滑相对风险（RR）和RR >；1的后验概率。结果我们估计了61 753例MS，粗略估计患病率为每10万人年132.0例，男女比为2.0。年龄标准化患病率为每10万人年123.5例。男性按年龄划分的患病率低于女性。所有指标都显示出南北梯度。女性有7例ACs，男性有5例ACs，显示出明显的过度风险（主要在西班牙北部），而女性和男性都有8例ACs，风险较低（主要在南部）。结论sour结果提供了西班牙ACs水平MS的最新患病率数据和地理分布，呈现南北梯度。我们的结果为未来管理西班牙MS影响的策略和理解因果假设铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.