{"title":"Hydrogel-Based Strategies for Managing Rheumatoid Arthritis: From Sustained Drug Release to Cell-Based Therapies","authors":"Woojin Back, and , Ji-Ho Park*, ","doi":"10.1021/acsbiomaterials.5c0059710.1021/acsbiomaterials.5c00597","DOIUrl":null,"url":null,"abstract":"<p >Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and joint damage, significantly impacting the quality of life. Traditional treatments for RA, including synthetic and biological disease-modifying antirheumatic drugs (DMARDs), are limited by issues such as systemic side effects, nonspecificity, and patient compliance challenges. Recently, hydrogel-based drug delivery systems have emerged as promising alternatives, providing localized, sustained, and stimuli-responsive therapeutic release. Hydrogels, with their high-water content and biocompatibility, enable the encapsulation and controlled delivery of various drugs including DMARDs, corticosteroids, and immunomodulatory agents. This review provides a comprehensive overview of recent advancements in hydrogel-based strategies for RA treatment, focusing on three key applications: (1) sustained DMARD delivery, (2) composite hydrogels integrating nanomaterials to impart additional disease-modifying properties such as targeted and controlled release of multiple drugs, including hydrophobic ones, and (3) hydrogel-mediated immunosuppressive cell delivery. By leveraging these multifunctional capabilities, hydrogels offer innovative solutions to overcome key challenges in conventional RA therapies. Although challenges in stability and scalability remain, ongoing advancements in hydrogel technology hold significant potential to transform RA management.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":"11 6","pages":"3262–3275 3262–3275"},"PeriodicalIF":5.4000,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c00597","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and joint damage, significantly impacting the quality of life. Traditional treatments for RA, including synthetic and biological disease-modifying antirheumatic drugs (DMARDs), are limited by issues such as systemic side effects, nonspecificity, and patient compliance challenges. Recently, hydrogel-based drug delivery systems have emerged as promising alternatives, providing localized, sustained, and stimuli-responsive therapeutic release. Hydrogels, with their high-water content and biocompatibility, enable the encapsulation and controlled delivery of various drugs including DMARDs, corticosteroids, and immunomodulatory agents. This review provides a comprehensive overview of recent advancements in hydrogel-based strategies for RA treatment, focusing on three key applications: (1) sustained DMARD delivery, (2) composite hydrogels integrating nanomaterials to impart additional disease-modifying properties such as targeted and controlled release of multiple drugs, including hydrophobic ones, and (3) hydrogel-mediated immunosuppressive cell delivery. By leveraging these multifunctional capabilities, hydrogels offer innovative solutions to overcome key challenges in conventional RA therapies. Although challenges in stability and scalability remain, ongoing advancements in hydrogel technology hold significant potential to transform RA management.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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