Advances in near-infrared responsive functional nanocomposites for bioimaging and antitumor research

IF 10.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2025-06-09 DOI:10.1016/j.jconrel.2025.113904

Juan Wang , Xing Gao , Lei Feng , Deliang Zhang , Shuhua Lv , Xiaoyin Li , Qingjia Liu , Dongkun Yu , Miaomiao Xing , Dongrun Li , Lulu Suo , Hongyu Mou , Jibin Song

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Abstract

Malignant tumors endanger human health, and their characteristics make treatment difficult. Near-infrared (NIR) light has become an ideal choice for biotherapy because it offers good penetrability and low damage. In recent years, NIR-based photothermal therapy, photodynamic therapy, photochemotherapy, and multimodal combination therapy have been developing rapidly, and the corresponding functional nanomaterials have been emerging. This review summarizes advances in NIR-triggered functional nanomaterials in tumor therapy, involving therapeutic reagent applications and synergistic and combined therapeutic systems. The nanomaterials have obvious advantages, such as the excellent performance of photothermal therapy- and photodynamic therapy-related nanomaterials, and multifunctional nanoplatforms capable of integrating multiple therapies. However, they face many challenges, such as the limitations of individual therapies and technical difficulties in the combined applications. In the future, we should focus on optimizing the materials, evaluating the combined therapeutic mechanism, innovating the technology and promoting clinical translation. The nanomaterials are expected to become the key means of clinical oncology treatment, bringing hope to overcome the malignant tumors.

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近红外响应功能纳米复合材料在生物成像和抗肿瘤研究中的进展

恶性肿瘤危害人类健康，其自身特点给治疗带来困难。近红外（NIR）光具有良好的穿透性和低损伤性，已成为生物治疗的理想选择。近年来，基于nir的光热疗法、光动力疗法、光化学疗法和多模态联合疗法发展迅速，相应的功能纳米材料不断涌现。本文综述了nir触发的功能纳米材料在肿瘤治疗中的研究进展，包括治疗试剂的应用以及协同和联合治疗系统。纳米材料具有明显的优势，如光热治疗和光动力治疗相关纳米材料的优异性能，以及能够集成多种治疗的多功能纳米平台。然而，他们面临着许多挑战，如个体治疗的局限性和联合应用的技术困难。今后应从优化材料、评价联合治疗机制、创新技术、促进临床转化等方面着手。纳米材料有望成为临床肿瘤治疗的关键手段，为战胜恶性肿瘤带来希望。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.