A Fully Integrated Wearable Sweat Sensing Patch for Online Analysis of Multiple Parkinson's Disease-Related Biomarkers

IF 27.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-06-09 DOI:10.1002/adma.202504534

Hao Zhao, Jing Bai, Xieli Zhang, Dan Li, Qi Chang, Yong Xia, Yan Liu, Samuel M. Mugo, Hongda Wang, Qiang Zhang

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Abstract

Parkinson's disease (PD) is marked by a prolonged asymptomatic “window period” (several years). Early prediction and diagnosis during this window are crucial, as timely interventions can slow disease progression. In this study, a fully integrated wearable sweat-sensing patch capable of real-time detection of three key PD biomarkers: L-Dopa, ascorbic acid, and glucose is developed. The system includes a biomimetic microfluidic module for sedentary sweat collection, an advanced electrochemical sensing platform for biomarker analysis, on-site signal processing circuitry for data management, and custom software for real-time data visualization. A universal strategy is proposed to significantly extend the stability of oxidase enzymes without activity loss, achieved through the design of Cu-oxidase hybrid nanoflowers. The patch is successfully tested on dozens of volunteers (healthy and PD patients in various stages), demonstrating its capability to monitor biomarkers in real time, assess PD progression, and optimize medication management.

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一种完全集成的可穿戴汗液传感贴片，用于在线分析多种帕金森病相关生物标志物

帕金森病（PD）的特点是无症状的“窗口期”延长（数年）。这一窗口期的早期预测和诊断至关重要，因为及时干预可以减缓疾病进展。在这项研究中，开发了一种完全集成的可穿戴式汗液传感贴片，能够实时检测PD的三种关键生物标志物：左旋多巴、抗坏血酸和葡萄糖。该系统包括一个用于久坐汗液收集的仿生微流控模块，一个用于生物标志物分析的先进电化学传感平台，用于数据管理的现场信号处理电路，以及用于实时数据可视化的定制软件。通过设计铜氧化酶杂交纳米花，提出了一种普遍的策略，以显着延长氧化酶的稳定性而不损失活性。该贴片成功地在数十名志愿者（健康和不同阶段的PD患者）身上进行了测试，证明了其实时监测生物标志物、评估PD进展和优化药物管理的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.