Palladium-Catalyzed [4 + 1] Annulation of Benzofuran-Derived Azadienes with Isocyanides

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-06-07 DOI:10.1021/acs.joc.5c00769

Ruoyu Zhang, Qingqing Wu, Xiuzhe Xie, Jingjing Zhao, Yun Chai, Bingchuan Yang, Puyu Zhang, Pan Li

引用次数: 0

Abstract

A palladium-catalyzed [4 + 1] annulation of benzofuran-derived azadienes and isocyanides has been developed. This protocol provides an efficient and practical approach to obtain diverse benzofuro[3,2-b]pyrrole derivatives in moderate to good yields. The reaction appears to proceed through Pd^II-assisted intramolecular Michael addition, followed by 5-exo-dig cyclization, aromatization, and subsequent base-assisted desulfonylation.

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钯催化苯并呋喃衍生氮杂烯与异氰酸酯的[4 + 1]环化反应

钯催化[4 + 1]环化苯并呋喃衍生的氮杂烯和异氰酸酯。该方案提供了一种有效和实用的方法，以中等到良好的收率获得各种苯并呋喃[3,2-b]吡咯衍生物。该反应似乎通过pdii辅助的分子内Michael加成进行，然后是5-外显式环化，芳构化和随后的碱辅助脱硫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.