The role of non-coding RNAs derived from macrophage exosomes in cardiovascular diseases.

IF 4.7 2区医学 Q1 NEUROSCIENCES

Journal of Physiology-London Pub Date : 2025-06-06 DOI:10.1113/JP288459

Wenyan Ding, Xiaofang Chen, Yuan Tian, Yanyue Wang, Chi Zhang

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引用次数: 0

Abstract

Cardiovascular disease is the predominant cause of mortality globally, with both morbidity and mortality rates escalating annually. Non-coding RNAs are essential in the regulation of cardiovascular disease. Exosomes are lipid bilayer vesicles that are released by many types of cells. They carry biomolecules such as proteins and nucleic acids (e.g. microRNAs, circular RNAs and long non-coding RNAs). The physiological condition of the mother cell significantly affects their composition and biological activity. In cardiovascular disorders, macrophages generate exosomes that facilitate intercellular communication, potentially resulting in new therapeutic strategies for these conditions. In this article, we examine the impact of exosomal non-coding RNAs derived from macrophages on the functionality and condition of immune cells, vascular smooth muscle cells, endothelial cells, cardiomyocytes and cardiac fibroblasts. They facilitate intercellular communication via several mechanisms. Non-coding RNAs generated from macrophage exosomes significantly influence cellular functional states and might offer new approaches for preventing and treating cardiovascular disorders. Owing to insufficient clinical evidence, additional extensive investigations are required to assess the therapeutic potential of these non-coding RNAs in cardiovascular disorders.

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巨噬细胞外泌体衍生的非编码rna在心血管疾病中的作用。

心血管疾病是全球死亡的主要原因，发病率和死亡率每年都在上升。非编码rna在心血管疾病的调控中是必不可少的。外泌体是由许多类型的细胞释放的脂质双分子层囊泡。它们携带生物分子，如蛋白质和核酸（如微rna、环状rna和长链非编码rna）。母细胞的生理状况对其组成和生物活性有显著影响。在心血管疾病中，巨噬细胞产生促进细胞间通讯的外泌体，可能导致针对这些疾病的新治疗策略。在本文中，我们研究了来自巨噬细胞的外泌体非编码rna对免疫细胞、血管平滑肌细胞、内皮细胞、心肌细胞和心脏成纤维细胞的功能和状况的影响。它们通过几种机制促进细胞间的交流。巨噬细胞外泌体产生的非编码rna显著影响细胞功能状态，可能为预防和治疗心血管疾病提供新的途径。由于临床证据不足，需要进一步的广泛研究来评估这些非编码rna在心血管疾病中的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physiology-London 医学-神经科学

CiteScore

9.70

自引率

7.30%

发文量

817

审稿时长

2 months

期刊介绍： The Journal of Physiology publishes full-length original Research Papers and Techniques for Physiology, which are short papers aimed at disseminating new techniques for physiological research. Articles solicited by the Editorial Board include Perspectives, Symposium Reports and Topical Reviews, which highlight areas of special physiological interest. CrossTalk articles are short editorial-style invited articles framing a debate between experts in the field on controversial topics. Letters to the Editor and Journal Club articles are also published. All categories of papers are subjected to peer reivew. The Journal of Physiology welcomes submitted research papers in all areas of physiology. Authors should present original work that illustrates new physiological principles or mechanisms. Papers on work at the molecular level, at the level of the cell membrane, single cells, tissues or organs and on systems physiology are all acceptable. Theoretical papers and papers that use computational models to further our understanding of physiological processes will be considered if based on experimentally derived data and if the hypothesis advanced is directly amenable to experimental testing. While emphasis is on human and mammalian physiology, work on lower vertebrate or invertebrate preparations may be suitable if it furthers the understanding of the functioning of other organisms including mammals.